Clinical Medicine Flashcards

1
Q

What is the single item question to screen for alcohol use disorder?

A

How many times in the past year have you had X or more drinks in a day?

X = 5 for men

X = 4 for women

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2
Q

On neck inspection, where do you most commonly see a thyroglossal duct cyst?

A

Midline, at the level of the thyroid gland

Usually assoicated with the hyoid bone too (moves with tongue extension)

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3
Q

Do thyroidal neck masses usually move with swallowing?

A

Yes

(fixed masses are likely not thyroid)

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4
Q

Describe the presenting characteristics of a breast fibroadenoma (5)

A
  • Firm
  • Round
  • Mobile
  • Nontender
  • Age <35 years old

Fibroadenoma = benign

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5
Q

List 3 non-endocrine signs of a thyroid mass

A

Dysphonia, dysphagia, dyspnea

(Usually develop in this order)

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6
Q

The DSM-5 defines substance use disorder as the presene of at least ___/11 criteria

A

The DSM-5 defines substance use disorder as the presene of at least 2 /11 criteria

Impaired control:

(1) taking more or for longer than intended
(2) unsuccessful efforts to stop or cut down use
(3) spending a great deal of time obtaining, using, or recovering from use
(4) craving for substance

Social impairment:

(5) failure to fulfill major obligations due to use
(6) continued use despite problems caused or exacerbated by use
(7) important activities given up or reduced because of substance use

Risky use:

(8) recurrent use in hazardous situations
(9) continued use despite physical or psychological problems caused or exacerbated by substance use

Pharmacologic dependence:

(10) tolerance to effects of the substance
(11) withdrawal symptoms when not using or using less

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7
Q

List 3 possible causes of bloody nipple discharge

What other nipple findings would make you concerned for a malignant etiology?

A
  • Nipple trauma
  • Intraductal papilloma (benign)
  • Carcinoma (malignant)
    • Nipple retraction
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8
Q

List 3 possible causes of breast erythema and warmth

A
  • Inflammatory breast cancer*
  • Abscess
  • Mastitis

*malignant

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9
Q

What is Modigliani syndrome?

A

Patients who have pronounced neck lordosis may look like they have a goiter

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10
Q

What is the single best time of day to measure cortisol in a case of cortisol excess?

A

12 am (midnight)

(8am in cortisol deficiency)

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11
Q

What is the single best time of day to measure cortisol in a case of cortisol deficiency?

A

8 am

(12am for cortisol excess)

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12
Q

How is Brief Intervention (BI) different from other substance abuse therapies?

A

Based on a harm reduction paradigm

  • Emphasizes reduction in use rather than abstinence-only
  • Goal is to reduce the risk of negative consequenes of drug use

State recommendation clearly, but work with pt to establish goals rather than telling them what to do

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13
Q

The 11 criteria for substance use disorder are clustered into 4 groups

What are the groups?

A
  • Impaired control
  • Social impairment
  • Risky use
  • Pharmacologic dependence

2/11 criteria required for diagnosis of substance use disorder

Impaired control:

(1) taking more or for longer than intended
(2) unsuccessful efforts to stop or cut down use
(3) spending a great deal of time obtaining, using, or recovering from use
(4) craving for substance

Social impairment:

(5) failure to fulfill major obligations due to use
(6) continued use despite problems caused or exacerbated by use
(7) important activities given up or reduced because of substance use

Risky use:

(8) recurrent use in hazardous situations
(9) continued use despite physical or psychological problems caused or exacerbated by substance use

Pharmacologic dependence:

(10) tolerance to effects of the substance
(11) withdrawal symptoms when not using or using less

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14
Q

What anatomical landmark lies just superior to the thyroid isthmus?

A

Cricoid cartilage

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15
Q

What are the CAGE questions to screen for an alcohol use disorder?

A
  • Have you ever felt the need to Cut down on drinking?
  • Have you ever been Annoyed by criticism of drinking?
  • Have you ever had Guilty feelings about drinking?
  • Have you ever taken a morning Eye opener?

Response of ≥ 2 is considered a positive screen

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16
Q

In Cushing’s syndrome, 24h free cortisol will be ___ times the normal amount

A

In Cushing’s syndrome, 24h free cortisol will be 3 times the normal amount

17
Q

List 3 things that can cause decreased cortisol binding globulin

What is the effect on free cortisol?

A
  • Genetic deficiency
  • Nephrotic syndrome
  • Androgens
  • > increased free cortisol
  • In these cases, measure total cortisol instead*
18
Q

List 2 things that can cause increased cortisol binding globulin

What is the effect on free cortisol?

A
  • OCPs (estrogen)
    • Increases CBG production
  • Hyperthyroid
19
Q

What findings on a breast exam would be concerning for Paget’s disease of the breast?

A

Rash and ulceration of the nipple

Note: Paget’s disease of the breast is not related to Paget’s disease of the bone ¯_(ツ)_/¯

20
Q

What are the 2 questions that make up the NIDA substance use “quick screen”?

A

In the past year, how often have you…

Used prescritption drugs for non-medical reasons?

Used illegal drugs?

At least 1 time = positive screen

21
Q

Which nerve is most likely to be injured during thyroid surgery?

A

Left recurrent laryngeal nerve

Supplies all intrinsic muscles of the larynx except the cricothyroid m.

22
Q

List 4 findings from the visual breast exam that would be concerning for malignancy

A
  • Abnormal contours (lumps)
  • Nipple retratction
  • Dimpling
  • Orange peel skin (Peu d’orange)
23
Q
A

A - Urine or saliva

24
Q

Describe the low dose dexamethasone suppression test

A
  • Give 1mg dexamethasone at 12am
  • Measure serum cortisol at 8am
    • Cortisol at 8am will be elevated in Cushing’s
25
Q

A 58 year old patient presents with itching, burning, and a scaly rash on the nipple.

What is the most likely diagnosis?

A

Paget’s disease of the breast

26
Q

What is the circled structure?

A

Esophagus

27
Q

A 27 year old women presents with a 1cmx1cm mass in the right breast. The mass is mobile, rubbery, and nontender with no overlying skin changes

What is the most likely diagnosis?

A

Fibroadenoma

28
Q

· The severity of the Substance Use Disorder is defined as:

  • Mild:
  • Moderate:
  • Severe:
A
  • Mild: 2-3 criteria
  • Moderate: 4-5 criteria
  • Severe: ≥6 criteria

Impaired control:

(1) taking more or for longer than intended
(2) unsuccessful efforts to stop or cut down use
(3) spending a great deal of time obtaining, using, or recovering from use
(4) craving for substance

Social impairment:

(5) failure to fulfill major obligations due to use
(6) continued use despite problems caused or exacerbated by use
(7) important activities given up or reduced because of substance use

Risky use:

(8) recurrent use in hazardous situations
(9) continued use despite physical or psychological problems caused or exacerbated by substance use

Pharmacologic dependence:

(10) tolerance to effects of the substance
(11) withdrawal symptoms when not using or using less