Clinical Blood Flashcards

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1
Q

Anaemia

A

Reduced hematocrit; reduction in hb conc. In blood; due to acute traumaa, chronic bleeding (PUD & Gastric Ulcer); Spherocytosis; G6PD deficiency; SCA; malaria; folic acid & B12 deficiency (defective DNA synthesis; thalassemia; iron deficiency

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2
Q

Anisocytosis

A

RBC of unequal size; may be seen in anaemia & thalassemia

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3
Q

Poikilocytes

A

Abnormally shaped RBC; Greater than 10% of total population

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4
Q

Hereditary spherocytosis

A

RBC lose their biconcavity & become spherical in shape;

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5
Q

Sickle Cell Anaemia

A

Glu(6)Val mutation; Autosplenectomy; vaso-occlusive crisis; hemolytic anaemia; Aggregation of deoxygenated HbS to form long filament like structures

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6
Q

Beta-Thalassemia

A

Deficient synthesis of beta-chain; hypochromic microcytic anaemia; vertical trabeculae (hair on end); blood transfusion, iron chelation, marrow translplant; anisocytosis; poikilocytosis; hypochromic cells

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7
Q

Polycythemia

A

high conc. RBC caused by dehydration; increase in red cell mass; neoplasm of myeloid stem cells; increased EPO due to renal hypoxia; high altitude; EPO secreting tumours

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