Clinical Bits

Question 1

_____ is caused by mutations in the machinery that performs mismatch repair in humans.

Answer 1

Hereditary non-polyposis colorectal cancer (HNPCC)

Question 2

Hereditary non-polyposis colorectal cancer (HNPCC) is caused by _____.

Answer 2

mutations in the machinery that performs mismatch repair in humans.

Question 3

Mutations in genes that mediate NER lead to human genetic diseases including _____

Answer 3

Cockayne Syndrome (CS), Xeroderma pigmentosum (XP), and Trichothiodystrophy (TTD).

Question 4

Mutations in _____ lead to human genetic diseases including Cockayne Syndrome (CS), Xeroderma pigmentosum (XP), and Trichothiodystrophy (TTD).

Answer 4

genes that mediate NER