Clinical Applications Flashcards
What are the clinical applications of isosorbide dinitrate? (short-acting and long-acting)
- short-acting: prophylaxis and treatment of acute anginal attacks
- long-acting: prophylaxis of angina, treatment of chronic ischemic heart disease, diffuse esophageal spasm
What are the clinical applications of isosorbide 5-mononitrate
- prophylaxis of angina
- treatment of chronic ischemic heart diease
What are the clinical applications of nitroglycerin (short-acting, long-acting, and intravenous)
- short-acting: treatment of acute anginal attacks
- long-acting: prophylaxis of angina, treatment of chronic ischemic injury
- intravenous: unstable angina, stable angina
What are the clinical applications of sodium nitroprusside?
- hypertensive emergencies
- severe cardiac failure
- ergot alkaloid toxicity
What are the clinical applications of inhaled nitric oxide gas?
- neonatal respiratory failure
- perinatal hypoxia
- pulmonary hypertension
What are the clinical applications of phosphodiester type V inhibitors? What is specific to sildenafil?
- erectile dysfunction
- sildenafil: pulmonary hypertension
What are the clinical applications of dihydropyridines (calcium channel blockers)?
- exertional angina
- unstable angina
- coronary spasm
- hypertension
- hypertrophic cardiomyopathy
- Reynaud’s phenomenon
- pre-eclampsia
What are the clinical applications of benzothiazepine/diltiazem (calcium channel blocker)?
- Printzmetal’s or varient angina or chronic stable angina
- hypertension
- atrial fibrillation or flutter, paroxysmal supraventricular tachycardia
What are the clinical applications of phenylalkylamine/verapamil
- Printzmetal’s or varient angina or chronic stable angina
- hypertension
- atrial fibrillation or flutter, paroxysmal supraventricular tachycardia
What are the clinical applications of potassium channel openers? What is specific to minoxidil
- severe or refractory hypertension
- minoxidil: male pattern alopecia
What are the clinical applications of endothelia receptor antagonists?
-severe pulmonary hypertension
What are the clinical applications of hydralazine?
- moderate to severe hypertension
- severe heart failure
