clinical Flashcards
pyelonephritis?
inflammation of kidneys
nephrotoxicity?
renal damage due to toxins
pyuria?
standard level
increase wbc in urine - means infection
at least 10 WBC/m^2 of urine
proteinuria standard levels?
protein excretion more than 150mg/day
different types of haematuria?
visible -macro - visibly red
microscopic
dipstick - after dipstick
definition of microscopic haematuria?
more/equal to 3 abc in urine per high power field
standard level of oliguria?
urine output less than 0.5ml/kg/hour
anuria?
no urine output
polyuria?
urine output larger than 3L/24HRS
NOCTURIA definition?
waking up at night more than/equal to 1 occasion to pee
serum creatinine? measures?
waste product that comes from normal wear and tear - sign that kidneys don’t work well -
more kidney damage/more creatinine
normal gfr level? and what level does the kidney not work well?
more than/equal to 90 = 90-120
less than 60 = kidney doesn’t work well
microalbuminua?
can also do?
sensitive dipstick test that detects tiny amounts of albumin in urine
albumin:creatinine ratio to check for kidney damage
functions of kidney? 5
- regulate bp
- electrolyte balance(sodium/potassium/chlorine)
- excretory functions(drugs/urea)
- body fluid balance
- acid/base balance
chronic renal failure is?
gradual loss of kidney function
dialysis?
artificially removes waste products and extra fluid from blood - can be placed catheter form
like an artificial kidney
how can trauma occur to ureter?
cut or tied during hysterectomy or colon resection
trauma from surgery
obstruction of ureter occurs in what 3 ways?
intra-luminal - in lumen = stone
intra-mural - scar tissue/tumour
extra-luminal - pelvic mass/LN
tcc?
transitional cell carcinoma
hydronephrosis?
1/both kidneys become stretched and swollen - due to increased urine in them
renal colic?
pain in flanks - pain in lower back
two tumours in bladder?
squamous cell carcinoma
TCC of bladder
LUTS?
clinical symptoms involving bladder/urethra
voiding - poor stream, urinary retention, incontinence, incomplete voiding
storage - increase freq., increase urgency
urinary incontinence means?
loss of bladder control
pneumaturia?
air in urine - due to cold-vesical fistula - from colon
what is risk of bladder/renal cancer in patient with visible haematuria?
bladder = 25-30%
renal = 0.5-1%
pelvic floor dysfunction? lead to?
damage to pelvic floor muscles - lead to stress and incontinence
3 levels of control of micturition?
cortical centre - cortex - bladder sensation of fullness and inhibition of micturition
pons - micturition centre
sacral segments - micturition reflex - automatic/somatic/parasympathetic
mucturition cycle occurs how?
storage/filling phase
voiding phase
sympathetic & parasympathetic & somatic innervation on micturition?
sympathetic - relaxation of urethral sphincter -open
parasympathetic - contraction of detrusor muscle - squeeze out
somatic - relaxation of external urethral sphincter - open
acute urinary retention define?
main cause
painful
inability to void - with palpable and permissible bladder
-due to BPO
chronic urinary retention define?
MAIN CAUSE
painless
palpable and percussible bladder AFTER voiding
muscle detrusor inactivity
two types of chronic urinary retention?
high pressure or low pressure - bladder filling pressure
what can occur due to catheter?
diuresis - increase urine freq.
diagnosis of UTI requires what 2 things?
microbiological evidence & symptoms
2 types of UTI?
UNCOMPLICATED
COMPLICATED
MESANGIAL CELLS?
group of cells which support capillaries in glomeruli
albumin - filtration?
cannot be filtered - albumin cannot be filtered too large
4 presentations of Glomerulonephritis ?
haematuria
heavy proteinuria
slowly increasing proteinuria
acute renal failure
nephrotic syndrome? due to?
increase protein in urine -
due to damage to bv in kidney
main causes of haematuria?4
uti
urinary tract stone
urinary tract tumour
Glomerulonephritis
kimmelsteil-wilson lesion?
long standing diabetes - leading to kidney condition - affects the bv in the glomeruli -
signs of diabetic nephropathy?
first sign of diabetic kidney disease - albumin in urine - - microalbuminuria
sign of acute renal failure?
rapidly risisng creatinine
what properties make urine bacteriostatic? 3
low pH
high osmolarity
high ammonia - NH3
what contaminates the urine?
by terminal urethral flora
is contamination present in MSSU?
YES - but less contamination
results of MSSU culture means?
10^5 = infection present 10^3/4 = infection 50% if asymptomatic/ probable infection if symptoms
10^2 = no infection
hydroureter?
dilation/enlargement
HORMONES that the kidney produce? 3
erythropoietin
vit D
renin
how much of the cardiac output do kidneys take?
20-25%
what does creatine serum levels depend on? 4
age ethnicity gender weight muscle mass
classification of ckd?
1 to 5
what molecules do not cross filtration barrier?
abc/albumin/globulins
definition of ckd?
prescence of kidney damage - abnormal blood/urine etc
or
gfr less than 60 present for over/equal to 3 months
what two things used to see prognosis of ckd?
by albumin levels in urine and gfr level
RRT includes?
dialysis and transplant
PCR & ACR means?
24hr UC MEAN?
pcr - protein creatinine ratio
acr- albumin creatinine ratio
24HR urine collection
complications of prolonged low eGFR? 6
anaemia bone disease fluid overload hypertension acidosis electrolyte imbalance
size of prostate? measured in?
cc-cubic centimetres
any! continuously growing as you grow up
prostatic zones - which Is most likely for prostate cancer?
peripheral zone
benign prostatic hyperplasia?
occurs In what prostatic zone?
fibromuscular and glandular hyperplasia
transition zone
assessment of Luts by? 2
IPSS score sheet -prostate symptoms
freq volume charts
two types of LUTS? examples of each
voiding - hesitancy.poor stream, dribbling, incomplete emptying
storage - freq, nocturia, urgency, urge
avg number of times to go to bathroom a day?
4-8
examination looking for?
penis?
DRE?
PHIMOSIS
external urethral meatus
prostate size
nodules/firmness
what bloods to test for prostate?
PSA
goes up as prostate size goes up
size of prostate mean?
size doesn’t mean anything - can have large and no symptoms etc
all about investigations and symptoms
flow rate study values for BPO?
Qmax less than 10ml/s - means most likely BOO
ALPHA BLOCKERS?
mechanism?
used in BOO
tamsulosin
relaxes smooth muscle of prostate and bladder neck
5A-reductase inhibitors?
mechanism?
used in BOO
finasteride
dutasteride
converts testosterone into something else
reduces prostate size
TURP?
SCOPE into urethra
and removes parts of prostate
followed by use of catheter
two ways of catheter?
suprapubic
urtheral
uterocele?
doesn’t allow urine to flow - blocks it
too narrow
bulge in ureter
nephrostomy?
tube through back to drain kidney directly
CT UROGRAM?
INJECT dye in and take x rays to see clear flow of urinary tract
common place for upper tract TCC? can lead to?
renal pelvis and collecting system
lead to bladder TCC
END STAGE RENAL disease? gfr is?
irreversible damage to persons kidneys
gfr is less than 15
advanced ckd is called?
uraemia - increased level of urea in blood - should be removed by kidneys
when is RRT indicated?
when eGFR IS less than 10
requirements in a dialysis? 4
semipermeable membrane
blood exposure to membrane
dialysis access
anticoagulation
what are the markers on how well dialysis works?
creatinine and urea
what restrictions are there in dialysis patients? 2
fluid and diet
what risk is there in haemodialysis?
blood clots risk and air embolus risk!
how peritoneal dialysis works?
2 types - EXPLAIN
via a cuffed catheter using peritoneal membrane
CAPD - DURING DAY
APD - OVERNIGHT
ARRYHTMIAS are related to what?
related to removal of K electrolyte
mortality of dialysis patients?
increased
what is conservative kidney management?
supportive care
end of life care
just priority to symptoms management
2 principles/mechanisms of dialysis? explain each
diffusion and ultra filtration
diffusion - equalising and balancing on both sides
ultrafiltration - shifting fluid and some molecules
pyuria?
standard level?
presence of pus cells in urine
more than 10 WBC
means presence of inflammation/uti
pyelonephritis?
infection in upper urinary tract ivolving kidneys