Clindamycin

Question 1

Clindamycin (Cleocin)

Answer 1

IV, PO, Topical

Question 2

Mechanism of Action

Answer 2

inhibit 50S bacterial ribosomal protein symthesis, because its actively transported into macrophages, it can penetrate some abscesses; bacteriostatic or bactericidal depending on organism

Question 3

Antibacterial Spectrum

Answer 3

Excellent anaerobic and gram +
almost no gram -
alternative to pcn and cephalosporins when gram + is needed
skin and soft tissue infections (cellulitis) with pcn allergy
Mild aspiration pneumonias
Topical for acne
CA-MRSA

Question 4

Adverse Drug Reactions

Answer 4

Allergic reactions (rare)
GI Intolerance
Clostridium difficile diarrhea
Avoid inj in neonates