Classifications

Question 1

Enlist polyene antifungal antibiotics

Answer 1

Amphotericin b
Nystatin
Natamycin(pimaricin)

Question 2

Source of amp.b

Answer 2

Streptomyces. nodosus

Question 3

CmbinTion of ___$____ used for cryptococcal infection meningitis.

Answer 3

Amphotericin b $ flucytosine

Question 4

S. Of nystatin?

Answer 4

St. Noursei

Question 5

Nystatin is DOC for___?

Answer 5

Intestinal moniliasis

Question 6

Natamycin is DOC for___

Answer 6

Fungal keratitis

Question 7

Name some systemic antifungal agents

Answer 7

Polyene af antbiotic

Azoles

Question 8

Name some topical af agents

Answer 8

Griseofulvin
Undecylenic acid
Salicyclic
Benzoic
Tolnaftate
Ciclopirox olamine
Haloprogin
Candidicin
Iodochlorhydroxyquin
Cuprimyxin
Imidazoles
Amorolfine
Terbinafine

Question 9

Azoles include_____

Answer 9

Imidazoles

Triazoles

Question 10

Name some topical imidazoles

Answer 10

Clotrimazole
Econazole
Miconazole

Question 11

Name some systemic imidazoles?

Answer 11

Ketoconazole

Thiabendazole

Question 12

Name systemic triazoles?

Answer 12

Fluconazole

Itraconazole

Question 13

Triazoles inhibit ______?

Answer 13

Fungal cytochrome P450 enzyme

Lanosine 14-alpha demethylase which cnverts lanosterol to ergosterol

Question 14

Triazoles are less toxic then imidazoles. T/F?

Answer 14

True

Question 15

___is the frat orally effective broad spctrm antifungal drug?

Answer 15

Ketoconazole

Question 16

_____is used for histo,blasto,coccidioido,crypto mycosis and mucocutaneous candidiasis?

Answer 16

Ketoconazole

Question 17

Azoles have poor ___ penetration?

Answer 17

CSF

Question 18

_____ undergo intesive hepatic metabolism and excreated in urine and faeces?

Answer 18

Fluconazole

Question 19

Ketoconazole causes _____ enzyme inhibition?

Answer 19

Microsomal

Question 20

Ketoconazole also inhibits ____?

Answer 20

Steroidogenesis

Question 21

K.zole have _____ effects

Answer 21

Teratogenic

Cause gi distrbnces hormonal n repductive disorders in dog.

Question 22

F.zole have high _____ and low____?

Answer 22

High tissue penetrability and low nephrotoxicity

Question 23

____is narrow spctrm fungistatic drug?

Answer 23

Flucytosine

Question 24

Flucytosine converts to ____ by _____ in fungal but not in the mammalian cells.

Answer 24

Antibetabolite 5-flurouracil (5-FU) by cytosine deaminase

Question 25

5-fu inhibits____ and thus ______?

Answer 25

Thymidylate synthetase and thus DNA synthesis

Question 26

Griseofulvin is obtained from.? And it is ___spctrm?

Answer 26

Penicillium griseofulvum

Narrow

Question 27

_______ intake promotes absorption of griseofulvin from GIT

Answer 27

High dietary fat

Question 28

G.fulvin intracts with ____ thus causing distruption of _____ .

Answer 28

Polymerized microtubules

Mitotic spindle

Question 29

G.fulvin deposits in ____ cells of stratum corneum.

Answer 29

Keratin precursor

Question 30

G.fulvin is DOC FOR__?

Answer 30

Ringworms in calves

Question 31

Undecyclenic acid is used for rx of___?

Answer 31

Fungal mastitis

Question 32

Salicyclic acid is used for rx of ______?

Answer 32

Chronic superficial dermatomycoses

Question 33

3%____+6%_____are used to prepare______(antifungl ointment)

Answer 33

Salicyclic acid
Benzoic acid
Whitfield ointment

Question 34

Benzoic acid hv both _____ and ____ activity?

Answer 34

Fungistatic n keratolytic

Question 35

______is active against dermatophytes but not against candida and bacteria

Answer 35

Tolnaftate

Question 36

________ used to treat dermatomycoses

Answer 36

Griseovulvin orally