Antiviral Drugs Flashcards by Honey Singh

Enlist Antivirals based on MOA

1-Prevnting v. Attchmnt n pentration of host cell
2- neuraminidase inhibitors
3-transcription analogs
4-late translation inhibitors
5-DNA polymerase n synthesis inhibitors
6-reverse transcriptase inhibitors
7-protease inhibitors
8-intrfrnce in prot. Synth.
9- intrfrnce with viral maturation
10- host immunomodulators

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Prevnting v. Attchmnt n pentration of host cell. Egs

Amantadine

Rimantadine

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neuraminidase inhibitors egs

Oseltamivir tamiflu

Zanamivir releniza

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transcription analogs egs

Idoxuridine
Ribavirin
Trifluorothymidine( trifluridine )

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late translation inhibitors egs

Metihisazone

Interferons

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DNA polymerase n synthesis inhibitors egs

Acyclovir
Famciclovir
Ganciclovir
Cytarabine
Vidarabine
Foscarnet

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reverse transcriptase inhibitors egs

Zidovudine
Didanosine
Stavudine

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protease inhibitors egs

Sanquinavir
Indinavir
Ritonavir
Nelfinavir

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intrfrnce in prot. Synth

Mitomycin

Puromycin

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intrfrnce with viral maturation

Rifamycin

Streptovaricin

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host immunomodulators egs

Interferons
Gamma globulin
Poly1
Poly C
BRL-5907
Levamisol

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Based on type of virus affected… Enlist

Antiherpes v.
Antiretro
Antiinfluenza
Antipox
Antiviral antibiotics
Non selective

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Egs of antiherpes

Vidarabine
Cytarabine
Gancicolovir
Acyclovir

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Antiretro egs

Zidovudine
Indinavir
Ritonavir
Nelfinavir

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Anti influenza egs

Amantidine
Rimantadine
Zanamivir

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Antipox egs

Methisazone

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Antiviral antibiotics egs

Actinomycin -D
Mitomycin
Puromycin

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Non selective egs

Interferon
Interferons inducer
Y-globulins
Levamisol

First av drug used in man

Idoxuridine ( pyrimidine nucleoside )

MOA of idoxuridine

Being thymidine analog, it cpetes with thymidine n gets incorportated in DNA resulting in formation of faulty DNA which breaks down easily.

Idoxuridine is affective against___ only

DNA

Idoxuridine is used against rx of ______

Corneal n skin infections

Trifluridine is analog of?

Deoxythymidine

Trifluridine is DOC for…

Herpes simplex keratitis in man

Cytarabine has activity against...

Herpes Pox Vaccinia Rabies

Vidarabine is ____analog

Adenine

MOA of vidarabine

It is phosphorylated by cellular enzyme to triphosphate | Inhibits viral n human DNA polymerase n thus DNA synthesis

Vidarabine is used for rx of ...

Ocular herpes infection Herpes simplex encephalitis Mucocutaneous herpes Pox v infection

Higher dosesof vidarabine produces...

Bone marrow and cns toxicity

Ribavirin is...

Synthetic purine Analog of guanosine Broad spectrm AV

Ribavirin acts against...

Adeno,herpes,orthomyxo,paramyxo,pox,picorna, rhabado ,rota n retro

Ribavirin MOA

Its mono n triphosphate derivatives generated intracellularly inhibit GTP and viral RNA and polypeptide synthesis

Acyclovir is...

Deoxyguanosine analog

Acyclovir is phosphorylated to _____ by virus specific ____ and is again phosphorylated to _____by _______

Acyclovir-monophosphate Thymidine kinase Acyclovir triphohte Cellular kinase

Acyclovir is used for rx of...

Chicken pox | Feline herpes virus

Foscarnet acts by inhibiting____and ______?

Dna polymerase and reverse transcriptase

Zidovudine is analog of...

Thymidine

Zidovudine rx against...

Retrovirus and HIV

Zidovudine inhibits...

Viral reverse transcriptase

Methisazone effective against_______

Pox and adeno viruses | Small pox in man

Amantadine is effective against...

Influenza v

MOA of amantadine..

Blocks the pentration of v into host cell n inhibits uncoating of virus particle. Also interferes with early stage of viral mRNA trancsription

Oseltamivir n zanamivir inhibits ____ enzyme

Neuraminidase | Rx for bird flu

Classify antivirals?

Based on mechenism of action | Based on types of virus affected