Antiviral Drugs Flashcards
Enlist Antivirals based on MOA
1-Prevnting v. Attchmnt n pentration of host cell 2- neuraminidase inhibitors 3-transcription analogs 4-late translation inhibitors 5-DNA polymerase n synthesis inhibitors 6-reverse transcriptase inhibitors 7-protease inhibitors 8-intrfrnce in prot. Synth. 9- intrfrnce with viral maturation 10- host immunomodulators
Prevnting v. Attchmnt n pentration of host cell. Egs
Amantadine
Rimantadine
neuraminidase inhibitors egs
Oseltamivir tamiflu
Zanamivir releniza
transcription analogs egs
Idoxuridine
Ribavirin
Trifluorothymidine( trifluridine )
late translation inhibitors egs
Metihisazone
Interferons
DNA polymerase n synthesis inhibitors egs
Acyclovir Famciclovir Ganciclovir Cytarabine Vidarabine Foscarnet
reverse transcriptase inhibitors egs
Zidovudine
Didanosine
Stavudine
protease inhibitors egs
Sanquinavir
Indinavir
Ritonavir
Nelfinavir
intrfrnce in prot. Synth
Mitomycin
Puromycin
intrfrnce with viral maturation
Rifamycin
Streptovaricin
host immunomodulators egs
Interferons Gamma globulin Poly1 Poly C BRL-5907 Levamisol
Based on type of virus affected… Enlist
Antiherpes v. Antiretro Antiinfluenza Antipox Antiviral antibiotics Non selective
Egs of antiherpes
Vidarabine
Cytarabine
Gancicolovir
Acyclovir
Antiretro egs
Zidovudine
Indinavir
Ritonavir
Nelfinavir
Anti influenza egs
Amantidine
Rimantadine
Zanamivir
Antipox egs
Methisazone
Antiviral antibiotics egs
Actinomycin -D
Mitomycin
Puromycin
Non selective egs
Interferon
Interferons inducer
Y-globulins
Levamisol
First av drug used in man
Idoxuridine ( pyrimidine nucleoside )
MOA of idoxuridine
Being thymidine analog, it cpetes with thymidine n gets incorportated in DNA resulting in formation of faulty DNA which breaks down easily.
Idoxuridine is affective against___ only
DNA
Idoxuridine is used against rx of ______
Corneal n skin infections
Trifluridine is analog of?
Deoxythymidine
Trifluridine is DOC for…
Herpes simplex keratitis in man
Cytarabine has activity against…
Herpes
Pox
Vaccinia
Rabies
Vidarabine is ____analog
Adenine
MOA of vidarabine
It is phosphorylated by cellular enzyme to triphosphate
Inhibits viral n human DNA polymerase n thus DNA synthesis
Vidarabine is used for rx of …
Ocular herpes infection
Herpes simplex encephalitis
Mucocutaneous herpes
Pox v infection
Higher dosesof vidarabine produces…
Bone marrow and cns toxicity
Ribavirin is…
Synthetic purine
Analog of guanosine
Broad spectrm AV
Ribavirin acts against…
Adeno,herpes,orthomyxo,paramyxo,pox,picorna, rhabado ,rota n retro
Ribavirin MOA
Its mono n triphosphate derivatives generated intracellularly inhibit GTP and viral RNA and polypeptide synthesis
Acyclovir is…
Deoxyguanosine analog
Acyclovir is phosphorylated to _____ by virus specific ____ and is again phosphorylated to _____by _______
Acyclovir-monophosphate
Thymidine kinase
Acyclovir triphohte
Cellular kinase
Acyclovir is used for rx of…
Chicken pox
Feline herpes virus
Foscarnet acts by inhibiting____and ______?
Dna polymerase and reverse transcriptase
Zidovudine is analog of…
Thymidine
Zidovudine rx against…
Retrovirus and HIV
Zidovudine inhibits…
Viral reverse transcriptase
Methisazone effective against_______
Pox and adeno viruses
Small pox in man
Amantadine is effective against…
Influenza v
MOA of amantadine..
Blocks the pentration of v into host cell n inhibits uncoating of virus particle.
Also interferes with early stage of viral mRNA trancsription
Oseltamivir n zanamivir inhibits ____ enzyme
Neuraminidase
Rx for bird flu
Classify antivirals?
Based on mechenism of action
Based on types of virus affected
