Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Antifungal Agents > Antiviral Drugs > Flashcards

Antiviral Drugs Flashcards

1
Q

Enlist Antivirals based on MOA

A 
1-Prevnting v. Attchmnt n pentration of host cell
2- neuraminidase inhibitors
3-transcription analogs
4-late translation inhibitors
5-DNA polymerase n synthesis inhibitors
6-reverse transcriptase inhibitors
7-protease inhibitors
8-intrfrnce in prot. Synth.
9- intrfrnce with viral maturation
10- host immunomodulators
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Prevnting v. Attchmnt n pentration of host cell. Egs

A

Amantadine

Rimantadine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

neuraminidase inhibitors egs

A

Oseltamivir tamiflu

Zanamivir releniza

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

transcription analogs egs

A

Idoxuridine
Ribavirin
Trifluorothymidine( trifluridine )

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

late translation inhibitors egs

A

Metihisazone

Interferons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

DNA polymerase n synthesis inhibitors egs

A 
Acyclovir
Famciclovir
Ganciclovir
Cytarabine
Vidarabine
Foscarnet
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

reverse transcriptase inhibitors egs

A

Zidovudine
Didanosine
Stavudine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

protease inhibitors egs

A

Sanquinavir
Indinavir
Ritonavir
Nelfinavir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

intrfrnce in prot. Synth

A

Mitomycin

Puromycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

intrfrnce with viral maturation

A

Rifamycin

Streptovaricin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

host immunomodulators egs

A 
Interferons
Gamma globulin
Poly1
Poly C
BRL-5907
Levamisol
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Based on type of virus affected… Enlist

A 
Antiherpes v.
Antiretro
Antiinfluenza
Antipox
Antiviral antibiotics
Non selective
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Egs of antiherpes

A

Vidarabine
Cytarabine
Gancicolovir
Acyclovir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Antiretro egs

A

Zidovudine
Indinavir
Ritonavir
Nelfinavir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Anti influenza egs

A

Amantidine
Rimantadine
Zanamivir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Antipox egs

A

Methisazone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Antiviral antibiotics egs

A

Actinomycin -D
Mitomycin
Puromycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Non selective egs

A

Interferon
Interferons inducer
Y-globulins
Levamisol

19
Q

First av drug used in man

A

Idoxuridine ( pyrimidine nucleoside )

20
Q

MOA of idoxuridine

A

Being thymidine analog, it cpetes with thymidine n gets incorportated in DNA resulting in formation of faulty DNA which breaks down easily.

21
Q

Idoxuridine is affective against___ only

A

DNA

22
Q

Idoxuridine is used against rx of ______

A

Corneal n skin infections

23
Q

Trifluridine is analog of?

A

Deoxythymidine

24
Q

Trifluridine is DOC for…

A

Herpes simplex keratitis in man

25
Q

Cytarabine has activity against…

A

Herpes
Pox
Vaccinia
Rabies

26
Q

Vidarabine is ____analog

A

Adenine

27
Q

MOA of vidarabine

A

It is phosphorylated by cellular enzyme to triphosphate

Inhibits viral n human DNA polymerase n thus DNA synthesis

28
Q

Vidarabine is used for rx of …

A

Ocular herpes infection
Herpes simplex encephalitis
Mucocutaneous herpes
Pox v infection

29
Q

Higher dosesof vidarabine produces…

A

Bone marrow and cns toxicity

30
Q

Ribavirin is…

A

Synthetic purine
Analog of guanosine
Broad spectrm AV

31
Q

Ribavirin acts against…

A

Adeno,herpes,orthomyxo,paramyxo,pox,picorna, rhabado ,rota n retro

32
Q

Ribavirin MOA

A

Its mono n triphosphate derivatives generated intracellularly inhibit GTP and viral RNA and polypeptide synthesis

33
Q

Acyclovir is…

A

Deoxyguanosine analog

34
Q

Acyclovir is phosphorylated to _____ by virus specific ____ and is again phosphorylated to _____by _______

A

Acyclovir-monophosphate
Thymidine kinase
Acyclovir triphohte
Cellular kinase

35
Q

Acyclovir is used for rx of…

A

Chicken pox

Feline herpes virus

36
Q

Foscarnet acts by inhibiting____and ______?

A

Dna polymerase and reverse transcriptase

37
Q

Zidovudine is analog of…

A

Thymidine

38
Q

Zidovudine rx against…

A

Retrovirus and HIV

39
Q

Zidovudine inhibits…

A

Viral reverse transcriptase

40
Q

Methisazone effective against_______

A

Pox and adeno viruses

Small pox in man

41
Q

Amantadine is effective against…

A

Influenza v

42
Q

MOA of amantadine..

A

Blocks the pentration of v into host cell n inhibits uncoating of virus particle.
Also interferes with early stage of viral mRNA trancsription

43
Q

Oseltamivir n zanamivir inhibits ____ enzyme

A

Neuraminidase

Rx for bird flu

44
Q

Classify antivirals?

A

Based on mechenism of action

Based on types of virus affected

Antifungal Agents (3 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions