Antineoplastic Drugs Flashcards by Honey Singh

Enlist cytotoxic AC drugs..

Alkylating agents
Antimetabolites
Natural products
Misc agents
Radioactive isotopes

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Enlist AC drugs act by altering tissue hormonal milieu…

Corticosteroids
Estrogens
Progestins
Androgens
Antiestrogen
Thyroid hormone

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Enlist alkylating agents

Nitrogen mustards (derivatives of mustine )
Ethylenimine
Alkylsulfonate
Nitrosoureas
Triazene

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Enlist antimetabolites…

Folic acid antagonists
Purine antagonists
Pyrimidine antagonists

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Enlist natural products of anticancer drugs..

Cytotoxic antibiotics
Enzymes
Vinca alkaloids
Epipodophyllotoxin

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Enlist misc. agents of Ac drugs..

Platinum complex
Substituted urea
Adrenocortical suppressant
Taxanes
Hydrazine

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Enlist radioactive isotopes of ac drugs..

Sodium phosphate p32

Sodium iodide I131

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Egs of corticosteroids..

Prednisone

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Egs of estrogens…

Diethylestilbestrol n estradiol

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Egs of progestins…

Megestrol acetate

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Egs of androgens…

Testosterone

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Egs of antiestrogens…

Tamoxifen

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Egs of thyroid hormone..

Thyroxine

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Egs of nitrogen mustards..

Mechlorethamine
Cyclophosphamide
Chlorambucil
Mephalan

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Egs of ethylenimine…

Thiotepa

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Egs of alkylsulfonate..

Busulfan

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Egs of nitrosoureas…

Camustine
Lomustine
Streptozotocin

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Egs of triazene..

Dacarbazine

Egs of folic acid antagonists..

Methotrexate

Egs of purine antagonists..

6-mercaptopurine
6-thioguanine
Azarhioprine

Egs of pyrimidine antagonists..

5-fluorouracil

Cytarabine

Egs of cytotoxic antibiotics..

Actinomycin-D 
Doxorubicin
Daunorubicin
Mitomycin
Bleomycin

Egs of AC enzymes…

L-asparaginase

Egs of vinc alkaloids..

Vincristine
Vinblastine
Vindesine
Vinorelbine

Egs of epipodophyllotoxin..

Etoposide

Egs of platinum cmplex..

Cisplatin

Egs of substituted urea..

Hydroxyurea

Egs of adrenocortical spprsent..

Mitotane ( ORTHO PARA DDD )

Egs of taxanes..

Paclitaxel Docetaxel Docelatel

Egs of hydrazine

Procarbazine

Rx cyclophosphamide..

Lympholytic leukemia Lymphoma Sarcoma

Solid tumours in dog cat

Thiotepa

Busulfan used for...

Myloid l.kaemia | Affect pulmonary fibrosis

_______ has affinity for beta islets of langerhans n used to induce diabetes.

Streptozotocin

Cytarabine inhibits_____ and blocks_____?

DNA polymerase n blocks generation of cytidilic acid

Miomycin is derived from...?

Streptomyces caespitosus | Used in hodgkins disease.

Source of vinca alkaloids...?

Catharanthus roseus ( periwinkle plant )

Etoposide derived from...?

Mandrake root | Pdophyllum peltatum

Paclitaxel (taxanes) obtained from the bark of_____?

Western yew tree

Cisplatin has ______property?

Radiomimetic

Cisplatin is used for rx of...

Testicular and ovarian carcinoma

______ have greater killing efficacy of cytotoxic drugs.

Estrogens

Classification of anticancer drugs

Drugs acting directly on the cells (cytotoxic drug ) | Drugs acting by altering tissue hormonal milieu