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Antifungal Agents > Antineoplastic Drugs > Flashcards

Antineoplastic Drugs Flashcards

1
Q

Enlist cytotoxic AC drugs..

A 
Alkylating agents
Antimetabolites
Natural products
Misc agents
Radioactive isotopes
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2
Q

Enlist AC drugs act by altering tissue hormonal milieu…

A 
Corticosteroids
Estrogens
Progestins
Androgens
Antiestrogen
Thyroid hormone
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3
Q

Enlist alkylating agents

A 
Nitrogen mustards (derivatives of mustine )
Ethylenimine
Alkylsulfonate
Nitrosoureas
Triazene
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4
Q

Enlist antimetabolites…

A

Folic acid antagonists
Purine antagonists
Pyrimidine antagonists

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5
Q

Enlist natural products of anticancer drugs..

A

Cytotoxic antibiotics
Enzymes
Vinca alkaloids
Epipodophyllotoxin

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6
Q

Enlist misc. agents of Ac drugs..

A 
Platinum complex
Substituted urea
Adrenocortical suppressant
Taxanes
Hydrazine
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7
Q

Enlist radioactive isotopes of ac drugs..

A

Sodium phosphate p32

Sodium iodide I131

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8
Q

Egs of corticosteroids..

A

Prednisone

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9
Q

Egs of estrogens…

A

Diethylestilbestrol n estradiol

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10
Q

Egs of progestins…

A

Megestrol acetate

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11
Q

Egs of androgens…

A

Testosterone

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12
Q

Egs of antiestrogens…

A

Tamoxifen

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13
Q

Egs of thyroid hormone..

A

Thyroxine

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14
Q

Egs of nitrogen mustards..

A

Mechlorethamine
Cyclophosphamide
Chlorambucil
Mephalan

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15
Q

Egs of ethylenimine…

A

Thiotepa

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16
Q

Egs of alkylsulfonate..

A

Busulfan

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17
Q

Egs of nitrosoureas…

A

Camustine
Lomustine
Streptozotocin

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18
Q

Egs of triazene..

A

Dacarbazine

19
Q

Egs of folic acid antagonists..

A

Methotrexate

20
Q

Egs of purine antagonists..

A

6-mercaptopurine
6-thioguanine
Azarhioprine

21
Q

Egs of pyrimidine antagonists..

A

5-fluorouracil

Cytarabine

22
Q

Egs of cytotoxic antibiotics..

A 
Actinomycin-D 
Doxorubicin
Daunorubicin
Mitomycin
Bleomycin
23
Q

Egs of AC enzymes…

A

L-asparaginase

24
Q

Egs of vinc alkaloids..

A

Vincristine
Vinblastine
Vindesine
Vinorelbine

25
Q

Egs of epipodophyllotoxin..

A

Etoposide

26
Q

Egs of platinum cmplex..

A

Cisplatin

27
Q

Egs of substituted urea..

A

Hydroxyurea

28
Q

Egs of adrenocortical spprsent..

A

Mitotane ( ORTHO PARA DDD )

29
Q

Egs of taxanes..

A

Paclitaxel
Docetaxel
Docelatel

30
Q

Egs of hydrazine

A

Procarbazine

31
Q

Rx cyclophosphamide..

A

Lympholytic leukemia
Lymphoma
Sarcoma

32
Q

Solid tumours in dog cat

A

Thiotepa

33
Q

Busulfan used for…

A

Myloid l.kaemia

Affect pulmonary fibrosis

34
Q

_______ has affinity for beta islets of langerhans n used to induce diabetes.

A

Streptozotocin

35
Q

Cytarabine inhibits_____ and blocks_____?

A

DNA polymerase n blocks generation of cytidilic acid

36
Q

Miomycin is derived from…?

A

Streptomyces caespitosus

Used in hodgkins disease.

37
Q

Source of vinca alkaloids…?

A

Catharanthus roseus ( periwinkle plant )

38
Q

Etoposide derived from…?

A

Mandrake root

Pdophyllum peltatum

39
Q

Paclitaxel (taxanes) obtained from the bark of_____?

A

Western yew tree

40
Q

Cisplatin has ______property?

A

Radiomimetic

41
Q

Cisplatin is used for rx of…

A

Testicular and ovarian carcinoma

42
Q

______ have greater killing efficacy of cytotoxic drugs.

A

Estrogens

43
Q

Classification of anticancer drugs

A

Drugs acting directly on the cells (cytotoxic drug )

Drugs acting by altering tissue hormonal milieu

Antifungal Agents (3 decks)

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