Antineoplastic Drugs

Question 1

Enlist cytotoxic AC drugs..

Answer 1

Alkylating agents
Antimetabolites
Natural products
Misc agents
Radioactive isotopes

Question 2

Enlist AC drugs act by altering tissue hormonal milieu…

Answer 2

Corticosteroids
Estrogens
Progestins
Androgens
Antiestrogen
Thyroid hormone

Question 3

Enlist alkylating agents

Answer 3

Nitrogen mustards (derivatives of mustine )
Ethylenimine
Alkylsulfonate
Nitrosoureas
Triazene

Question 4

Enlist antimetabolites…

Answer 4

Folic acid antagonists
Purine antagonists
Pyrimidine antagonists

Question 5

Enlist natural products of anticancer drugs..

Answer 5

Cytotoxic antibiotics
Enzymes
Vinca alkaloids
Epipodophyllotoxin

Question 6

Enlist misc. agents of Ac drugs..

Answer 6

Platinum complex
Substituted urea
Adrenocortical suppressant
Taxanes
Hydrazine

Question 7

Enlist radioactive isotopes of ac drugs..

Answer 7

Sodium phosphate p32

Sodium iodide I131

Question 8

Egs of corticosteroids..

Answer 8

Prednisone

Question 9

Egs of estrogens…

Answer 9

Diethylestilbestrol n estradiol

Question 10

Egs of progestins…

Answer 10

Megestrol acetate

Question 11

Egs of androgens…

Answer 11

Testosterone

Question 12

Egs of antiestrogens…

Answer 12

Tamoxifen

Question 13

Egs of thyroid hormone..

Answer 13

Thyroxine

Question 14

Egs of nitrogen mustards..

Answer 14

Mechlorethamine
Cyclophosphamide
Chlorambucil
Mephalan

Question 15

Egs of ethylenimine…

Answer 15

Thiotepa

Question 16

Egs of alkylsulfonate..

Answer 16

Busulfan

Question 17

Egs of nitrosoureas…

Answer 17

Camustine
Lomustine
Streptozotocin

Question 18

Egs of triazene..

Answer 18

Dacarbazine

Question 19

Egs of folic acid antagonists..

Answer 19

Methotrexate

Question 20

Egs of purine antagonists..

Answer 20

6-mercaptopurine
6-thioguanine
Azarhioprine

Question 21

Egs of pyrimidine antagonists..

Answer 21

5-fluorouracil

Cytarabine

Question 22

Egs of cytotoxic antibiotics..

Answer 22

Actinomycin-D 
Doxorubicin
Daunorubicin
Mitomycin
Bleomycin

Question 23

Egs of AC enzymes…

Answer 23

L-asparaginase

Question 24

Egs of vinc alkaloids..

Answer 24

Vincristine
Vinblastine
Vindesine
Vinorelbine

Question 25

Egs of epipodophyllotoxin..

Answer 25

Etoposide

Question 26

Egs of platinum cmplex..

Answer 26

Cisplatin

Question 27

Egs of substituted urea..

Answer 27

Hydroxyurea

Question 28

Egs of adrenocortical spprsent..

Answer 28

Mitotane ( ORTHO PARA DDD )

Question 29

Egs of taxanes..

Answer 29

Paclitaxel
Docetaxel
Docelatel

Question 30

Egs of hydrazine

Answer 30

Procarbazine

Question 31

Rx cyclophosphamide..

Answer 31

Lympholytic leukemia
Lymphoma
Sarcoma

Question 32

Solid tumours in dog cat

Answer 32

Thiotepa

Question 33

Busulfan used for…

Answer 33

Myloid l.kaemia

Affect pulmonary fibrosis

Question 34

_______ has affinity for beta islets of langerhans n used to induce diabetes.

Answer 34

Streptozotocin

Question 35

Cytarabine inhibits_____ and blocks_____?

Answer 35

DNA polymerase n blocks generation of cytidilic acid

Question 36

Miomycin is derived from…?

Answer 36

Streptomyces caespitosus

Used in hodgkins disease.

Question 37

Source of vinca alkaloids…?

Answer 37

Catharanthus roseus ( periwinkle plant )

Question 38

Etoposide derived from…?

Answer 38

Mandrake root

Pdophyllum peltatum

Question 39

Paclitaxel (taxanes) obtained from the bark of_____?

Answer 39

Western yew tree

Question 40

Cisplatin has ______property?

Answer 40

Radiomimetic

Question 41

Cisplatin is used for rx of…

Answer 41

Testicular and ovarian carcinoma

Question 42

______ have greater killing efficacy of cytotoxic drugs.

Answer 42

Estrogens

Question 43

Classification of anticancer drugs

Answer 43

Drugs acting directly on the cells (cytotoxic drug )

Drugs acting by altering tissue hormonal milieu