Classification Of Antibiotics Flashcards
Understand how and why the antimicrobial drugs are classified into several groups
Way to classify antibiotics into categories?
- Chemical structure 2. Bactericidal or Bacteriostatic 3. Mode of action 4. Spectrum of antibacterial activity
mechanism of action
*inhibits cell wall synthesis *disturbs cell membrane function *inhibits protein synthesis *inhibits DNA doublication
Spectrum of antibacterial activity
Gram + / Gram -/ Gram + - / Mycoplasma/ Anaerobic / Leptospira & Bradyspira
pharmacokinetics
ADME
pharmacodynamics
What the drug does to the body
Bacteriostatics
Tetracycline/ Macrolide/ Lincosamide/ Phenicol/ Sulfamide/
Bactericidal types
Concentration dependant and Time dependant
Bactericidal concentration dependant
Flouroquinolone (-ve) / Aminoglycoside / polypeptides / Sulfamid + diamimipyrimidin
Bactericidal time depends
Beta-lactam/glycopeptide/ flouroquinolone in staph. / rifampicin
cell wall
beta lactam, bacitracin
cell membrane
polymycin, colistin, amphotericin
DNA
Quinolone
RNA
rifampin
protein synthesis
aminoglycoside, tetracycline, chloramphenicol, macrolide, lincomycin