Classic/Relevant Treatments Flashcards
Ethylene glycol/methanol intoxication
Fomepizole (alcohol dehydrogenase inhibitor)
Neisseria meningitidis
Penicillin/ceftriaxone
Rifampin (prophylaxis)
Clostridium botulinum
Antitoxin
Clostridium tetani
Antitoxin
Staphylococcus aureus
MSSA: nafcillin, oxacillin, dicloxacillin (antistaphylococcal penicillins)
MRSA: vancomycin, daptomycin, linezolid, ceftaroline
Streptococcus pyogenes
Penicillin prophylaxis
Streptococcus pneumoniae
Penicillin/cephalosporin (systemic infection, PNA), vancomycin (meningitis)
Streptococcus bovis
Penicillin prophylaxis; evaluation for colon cancer if linked to endocarditis
Enterococci
Vancomycin, aminopenicillins/cephalosporins
H flu (b)
Amoxicillin +/- clavulanate (mucosal infections), ceftriaxone (meningitis), rifampin (prophylaxis)
Legionella pneumophila
Macrolides (eg azithromycin)
Pseudomonas aeruginosa
Piperacillin/tazobactam, aminoglycosides, carbapenems
Treponema pallidum
Penicillin G
Chlamydia trachomatis
Doxycycline (+ ceftriaxone for gonorrhea coinfection), oral erythromycin to treat chlamydial conjunctivitis in infants
Rickettsia rickettsii
Doxycycline, chloramphenicol
Candida albicans
Topical azoles (vaginitis); nystatin, fluconazole, caspofungin (oral/esophageal); fluconazole, caspofungin, amphotericin B (systemic)
Cryptococcus neoformans
Induction with amphotericin B and flucytosine, maintenance with fluconazole (in AIDS patients)
Sporothrix schenkii
Itraconazole, oral potassium iodide
Pneumocystis jirovecii
TMP-SMX (prophylaxis and treatment in immunosuppressed patients, CD4 <200/mm3)
Toxoplasma gondii
Sulfadiazine + pyrimethamine
Malaria
Chloroquine, mefloquine, atovaquone/proguanil (for blood schizont), primaquine (for liver hypnozoite)
Trichomonas vaginalis
Metronidazole (patient and partner)
Influenza
Oseltamivir, zanamivir
CMV
Ganciclovir, foscarnet, cidofovir
Neisseria gonorrhoeae
Ceftriaxone (add doxycycline to cover likely concurrent C trachomatis)
Clostridium difficile
Oral metronidazole; if refractory, oral vancomycin
Mycobacterium tuberculosis
RIPE (rifampin, isoniazid, pyrazinamide, ethambutol)
UTI prophylaxis
TMP-SMX
Chronic hepatitis B or C
IFN-a (HBV and HCV); ribavirin, simeprevir, sofosbuvir (HCV)
Patent ductus arteriosus
Close with indomethacin; keep open with PGE analogs
Stable angina
Sublingual nitroglycerin
Hypercholesterolemia
Statin (first-line)
Buerger disease
Smoking cessation
Granulomatosis with polyangiitis (Wegener)
Cyclophosphamide, corticosteroids
Kawasaki disease
IVIG, high-dose ASA