classic labs/findings

Question 1

anti histone Ab

Answer 1

Drug induced SLE- hydralazine, procainamide, phenytoin, isoniazid

Question 2

apple core lesion on barium enema

Answer 2

colon cancer (left sided usually)

Question 3

basophilic nuclear remnant in RBC

Answer 3

Howel Jewell body - splenic nonfunction

Question 4

basophilic stippling of peripheral RBC

Answer 4

lead poisoning, sideroblastic anemia (ribosome aggregate)

Question 5

heinz body

Answer 5

G6PD, Hgb percipitate

Question 6

brown tumor of bone

Answer 6

hyperparathyroidism -osteitis fibrosa cystica (deposited hemosiderin from hemorrhage - brown)

Question 7

cardiomegaly with apical atrophy

Answer 7

Chagas disease

Question 8

circular grouping of dark tumor cells surrounding pale neurofibrils

Answer 8

homer-wright rossette (neuroblastoma, medduloblastoma)

Question 9

desquamated epithelial casts in sputum

Answer 9

asthma (curschmann spirals-bronchial asthma causes whorled mucous plugs)

Question 10

enlarged cells with intranuclear inclusion body

Answer 10

owl eye - CMV

Question 11

eosinophilic cytoplasmic inclusion of neuron

Answer 11

lewy body (parkinsons, lewy body dementia)- alpha synuclein

Question 12

eosinophilic globule in liver

Answer 12

councilman body - apoptosis of hepatocyte

Question 13

eosinophilic inclusion body in cytoplasm of hippocampal and cerebellar neuron

Answer 13

Negri body of rabies

Question 14

hair on end crew cut skull Xray

Answer 14

beta thalassemia, sickle cell (marrow expansion)

Question 15

granulomatous heart nodule

Answer 15

aschoff body (rheumatic fever)

Question 16

hexagonal, double pointed, needle like secretion in bronchial secretion

Answer 16

charcot leyden crystals- eosinophilic granules in asthma

Question 17

elevated D dimer

Answer 17

DIC, DVT, PE

Question 18

hypercoagulbility- migrating DVT and vasculitis

Answer 18

trousseau syndrome (adenocarcinoma pancreas, lung)

Question 19

hypochromic microcytic anemia

Answer 19

iron deficiency, lead posioning, thalassemia

Question 20

iron containing nodules in alveolar septum

Answer 20

ferruginous body of asbestosis

Question 21

monoclonal antibody spike

Answer 21

multiple myeloma (IgG, IgA)
MGUS
Waldenstrom (IgM) macroglobulinemia
primary amyloidosis

Question 22

narrowing of bowel lumen on barium XRay

Answer 22

Crohn’s- string sign

Question 23

polished, ivory like appearance of bone at cartilage erosion

Answer 23

eburnaiton (osteoarthritis induced bony sclerosis)

Question 24

protein aggregates in neurons of hyperphosphorylated tau

Answer 24

neurofibrillary tangle (alzheimer's), 
Pick bodies (frontal temporal dementia)

Question 25

psammoma body

Answer 25

meningioma, mesothelioma, papillary thyroid carcinoma, papillary serous carcinoma of endometrium and ovary

Question 26

renal epithelial cast in urine

Answer 26

intrinsic renal failure

Question 27

raised periosteum (codman’s triangle)

Answer 27

osteosarcoma, osteomyelitis, ewing sarcoma

Question 28

silver stianing spherical aggregation of tau protein in neuron

Answer 28

pick bodies of frontal temporal dementia

Question 29

soap bubble in femur/tibia on XR

Answer 29

giant cell tumor of bone

Question 30

stippled vaginal epithelial cells

Answer 30

clue cells of Gardernella vaginalis vaginosis

Question 31

thrombi made of white and red layers

Answer 31

lines of zhan (arterial thrombus with layers of platelets and RBC)

Question 32

thyroid like appearance of kidney

Answer 32

chronic pyelonephritis

Question 33

increased uric acid

Answer 33

gout, lesch nyhan, tumor lysis syndrome, loop diuretic, thiazide diuretic

Question 34

waxy casts, low urine flow

Answer 34

chronic ESRD