Classic Labs/Findings 1 Flashcards
Anticentromere antibodies
Scleroderma (CREST)
Antidesmoglein (epithelial) antibodies
Pemphigus vulgaris (blistering)
Anti-GMB antibodies
Goodpasture’s Syndrome (glomerulonephritis and hemoptysis)
Antihistone Antibodies
Drug induced SLE (hydrazine, procainaminde, phenytoin, INH)
Anti-IgG antibodies
Rheumatoid arthritis (RF Rheumatoid Factor)
Antimitochondrial antibodies
Primary Biliary Cirrhosis (female, cholestasis, portal HTN)
Antineutrophil Cytoplasmic Antibodies (ANCAs)
C-ANCA (Wegner’s) P-ANCA (Churg Strauss, microscopic polyangitis)
Antinuclear Antibodies (ANAs: anti-Smith, and anti-dsDNA)
SLE (type II hypersensitivity)
Antiplatelet Antibodies
Idiopathic Thrombocytopenic Purpura
Anti-topoisomerase Antibodies
Diffuse system scleroderma
Anti-transglutaminase/anti-gliadin/anti-endomysial antibodies
Celiac disease (diarrhea, distention, weight loss)
Apple Core lesion on Xray
Colorectal cancer (left sided)
Azurophilic peroxidase-positive granular inclusions in granulocytes and myeloblasts
Auer rods (AML–especially the promyelocytic type)
Bacitracin response
Sensitive: Strep Pyogenes (group A), resistant Step Agalactiae (group B)
Bamboo spine on xray
Ankylosing spondylitis (chronic inflammatory arthritis, HLA-B27)
Basophilic nuclear remnants in RBCs
Howell Jolly Bodies (due to splenectomy or nonfunctional spleen)
Basophilic stippling of RBCs
Lead poisoning or sideroblastic anemia
Blood tap on TL
subarachnoid hemorrhage
boot shaped heart on xray
Tertralogy of Fallot, RVH
branching gram positive rods with sulfur granules
Actinomyces israelii
bronchogenic apical lung tumor on imaging
pancoast tumor (can compress sympathetic ganglion and cause Horner’s syndrome)
cardiomegaly with apical atrophy
Chagas disease (t. cruzi)
Brown tumor of bone
Hyperparathyroidism or osteitis fibrosa cystica (deposited hemosiderin from hemorrhage gives brown color)
cellular crescents in bowman’s capsule
rapidly progressive crescentic glomerulonephritis
chocolate cyst of ovary
endometriosis (usually bilateral)
circular grouping of dark tumor cells surrounding pale neurofibrils
Homer Wright rosettes (neuroblastoma, medulloblastoma retinoblastoma)
colonies of mucoid pseudomonas in lungs
cystic fibrosis (autosomal recessive mutation in CFTR resulting in fat soluble vitamin deficiency and mucous plugs)
decreased alpha-fetoprotein in amniotic fluid/maternal serum
Down’s Syndrome or other chromosomal abnormality
degeneration of dorsal column nerves
tabes dorsalis (tertiary syphilis), subacute combined degeneration (dorsal columns and lateral corticospinal both affected)
depigmentation of neurons in substantia nigra
Parkinson’s Disease (basal ganglia disorder, rigidity, resting tremor, bradykinesia)
desquamated epithelium casts in sputum
Curschmann’s spirals (bronchial asthma can result in whorled mucous plugs.)
disarrayed granulosa cells in eosinophilic fluid
Call-Exner bodies (granulosa-theca cell tumor of the ovary)
dysplastic squamous cervical cells with nuclear enlargement and hyperchromasia
Koilocytes (HPV: predisposes to cervical cancer)
enlarged cells with intranuclear inclusion bodies
“Owl’s eye” appearance of CMV
enlarged thyroid cells with ground-glass nuclei
“orphan annie eyes” nuclei (papillary carcinoma of the thyroid)
eosinophilic cytoplasmic inclusion in liver cell
Mallory bodies (alcoholic liver disease)
eosinophilic cytoplasmic inclusion in never cell
Lewy Body (parkinson’s disease)
eosinophilic globule in liver
councilman body (toxic or viral hepatitis, yellow fever)
eosinophilic inclusion bodies in cytoplasm of hippocampal nerve cells
Negrei bodies of rabies
extracellular amyloid deposition in gray matter of the brain
senile plaques (Alzheimer’s disease)
Giant B cells with bilobed nuclei with prominent inclusions
Reed-Sternberg cells (Hodgkin’s Lymphoma)
glomerulus like structures surrounding vessels in germ cells
schiller-duval bodies (yolk sac tumor)
“Crew-cut” appearance on xray
Beta-Thalassemia, sickle cell anemia (marrow expansion)
hCG elevated
Choriocarcinoma, hydatidiform mole (occurs with or without embryo)
heart nodules (granulomatous)
Aschoff bodies (rheumatic fever)
heterphile antibodies
Infectious mono (EBV)
hexagonal, double pointed, needle-like crystals in bronchial secretions
bronchial asthma (charcot-leyden crystals; eosinophilic granules)
high level of D-dimers
DIC, PE, DVT
hilar lymphadenopathy, peripheral granulomatous lesion in middle or lower lung lobes (can calcify)
Ghon Complex (primary TB)
“honeycomb lung” on xray or CT
interstitial pulmonary fibrosis