Classic Labs/Findings 1 Flashcards

1
Q

Anticentromere antibodies

A

Scleroderma (CREST)

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2
Q

Antidesmoglein (epithelial) antibodies

A

Pemphigus vulgaris (blistering)

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3
Q

Anti-GMB antibodies

A

Goodpasture’s Syndrome (glomerulonephritis and hemoptysis)

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4
Q

Antihistone Antibodies

A

Drug induced SLE (hydrazine, procainaminde, phenytoin, INH)

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5
Q

Anti-IgG antibodies

A

Rheumatoid arthritis (RF Rheumatoid Factor)

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6
Q

Antimitochondrial antibodies

A

Primary Biliary Cirrhosis (female, cholestasis, portal HTN)

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7
Q

Antineutrophil Cytoplasmic Antibodies (ANCAs)

A

C-ANCA (Wegner’s) P-ANCA (Churg Strauss, microscopic polyangitis)

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8
Q

Antinuclear Antibodies (ANAs: anti-Smith, and anti-dsDNA)

A

SLE (type II hypersensitivity)

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9
Q

Antiplatelet Antibodies

A

Idiopathic Thrombocytopenic Purpura

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10
Q

Anti-topoisomerase Antibodies

A

Diffuse system scleroderma

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11
Q

Anti-transglutaminase/anti-gliadin/anti-endomysial antibodies

A

Celiac disease (diarrhea, distention, weight loss)

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12
Q

Apple Core lesion on Xray

A

Colorectal cancer (left sided)

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13
Q

Azurophilic peroxidase-positive granular inclusions in granulocytes and myeloblasts

A

Auer rods (AML–especially the promyelocytic type)

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14
Q

Bacitracin response

A

Sensitive: Strep Pyogenes (group A), resistant Step Agalactiae (group B)

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15
Q

Bamboo spine on xray

A

Ankylosing spondylitis (chronic inflammatory arthritis, HLA-B27)

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16
Q

Basophilic nuclear remnants in RBCs

A

Howell Jolly Bodies (due to splenectomy or nonfunctional spleen)

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17
Q

Basophilic stippling of RBCs

A

Lead poisoning or sideroblastic anemia

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18
Q

Blood tap on TL

A

subarachnoid hemorrhage

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19
Q

boot shaped heart on xray

A

Tertralogy of Fallot, RVH

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20
Q

branching gram positive rods with sulfur granules

A

Actinomyces israelii

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21
Q

bronchogenic apical lung tumor on imaging

A

pancoast tumor (can compress sympathetic ganglion and cause Horner’s syndrome)

22
Q

cardiomegaly with apical atrophy

A

Chagas disease (t. cruzi)

23
Q

Brown tumor of bone

A

Hyperparathyroidism or osteitis fibrosa cystica (deposited hemosiderin from hemorrhage gives brown color)

24
Q

cellular crescents in bowman’s capsule

A

rapidly progressive crescentic glomerulonephritis

25
Q

chocolate cyst of ovary

A

endometriosis (usually bilateral)

26
Q

circular grouping of dark tumor cells surrounding pale neurofibrils

A

Homer Wright rosettes (neuroblastoma, medulloblastoma retinoblastoma)

27
Q

colonies of mucoid pseudomonas in lungs

A

cystic fibrosis (autosomal recessive mutation in CFTR resulting in fat soluble vitamin deficiency and mucous plugs)

28
Q

decreased alpha-fetoprotein in amniotic fluid/maternal serum

A

Down’s Syndrome or other chromosomal abnormality

29
Q

degeneration of dorsal column nerves

A

tabes dorsalis (tertiary syphilis), subacute combined degeneration (dorsal columns and lateral corticospinal both affected)

30
Q

depigmentation of neurons in substantia nigra

A

Parkinson’s Disease (basal ganglia disorder, rigidity, resting tremor, bradykinesia)

31
Q

desquamated epithelium casts in sputum

A

Curschmann’s spirals (bronchial asthma can result in whorled mucous plugs.)

32
Q

disarrayed granulosa cells in eosinophilic fluid

A

Call-Exner bodies (granulosa-theca cell tumor of the ovary)

33
Q

dysplastic squamous cervical cells with nuclear enlargement and hyperchromasia

A

Koilocytes (HPV: predisposes to cervical cancer)

34
Q

enlarged cells with intranuclear inclusion bodies

A

“Owl’s eye” appearance of CMV

35
Q

enlarged thyroid cells with ground-glass nuclei

A

“orphan annie eyes” nuclei (papillary carcinoma of the thyroid)

36
Q

eosinophilic cytoplasmic inclusion in liver cell

A

Mallory bodies (alcoholic liver disease)

37
Q

eosinophilic cytoplasmic inclusion in never cell

A

Lewy Body (parkinson’s disease)

38
Q

eosinophilic globule in liver

A

councilman body (toxic or viral hepatitis, yellow fever)

39
Q

eosinophilic inclusion bodies in cytoplasm of hippocampal nerve cells

A

Negrei bodies of rabies

40
Q

extracellular amyloid deposition in gray matter of the brain

A

senile plaques (Alzheimer’s disease)

41
Q

Giant B cells with bilobed nuclei with prominent inclusions

A

Reed-Sternberg cells (Hodgkin’s Lymphoma)

42
Q

glomerulus like structures surrounding vessels in germ cells

A

schiller-duval bodies (yolk sac tumor)

43
Q

“Crew-cut” appearance on xray

A

Beta-Thalassemia, sickle cell anemia (marrow expansion)

44
Q

hCG elevated

A

Choriocarcinoma, hydatidiform mole (occurs with or without embryo)

45
Q

heart nodules (granulomatous)

A

Aschoff bodies (rheumatic fever)

46
Q

heterphile antibodies

A

Infectious mono (EBV)

47
Q

hexagonal, double pointed, needle-like crystals in bronchial secretions

A

bronchial asthma (charcot-leyden crystals; eosinophilic granules)

48
Q

high level of D-dimers

A

DIC, PE, DVT

49
Q

hilar lymphadenopathy, peripheral granulomatous lesion in middle or lower lung lobes (can calcify)

A

Ghon Complex (primary TB)

50
Q

“honeycomb lung” on xray or CT

A

interstitial pulmonary fibrosis