Classic bone histology findings

Question 1

Osteoid matrix accumulation around trabeculae

Answer 1

Vitamin D deficiency (osteomalacia or rickets)

*The tricky thing here is that they don’t come out and say the matrix is unmineralized

Question 2

Trabecular thinning w/ few interconnections

Answer 2

Osteoporosis

Question 3

Subperiosteal resorption with cystic degeneration

Answer 3

Hyperparathyroidism

Question 4

Lamellar bone structure resembling a mosaic

Answer 4

Paget’s disease of bone

Question 5

Spongiosa filling the medullary cavity w/ no mature trabeculae

Answer 5

Osteopetrosis

Question 6

Name the classic bone histo findings for vitamin D rickets/osteomalacia

Answer 6

Unmineralized osteoid matrix accumulation around trabeculae

Question 7

Name the classic bone histo findings for osteoporosis

Answer 7

Trabecular thinning w/ few interconnections

Question 8

Name the classic bone histo findings for hyperparathyroidism

Answer 8

Subperiosteal resorption with cystic degeneration

Question 9

Name the classic bone histo findings for paget’s disease of bone

Answer 9

Lamellar bone structure resembling a mosaic

Question 10

Name the classic bone histo findings for osteopetrosis

Answer 10

Spongiosa filling the medullary cavity w/ no mature trabeculae