Class IV Antiarrhythmics

Question 1

Names Class IV Antiarrhythmics

Answer 1

Non dihydropyridine calcium channel blockers

Verapamil
(“very Vanilla”)

Diltiazem
(“Delicious dark choclate”)

Question 2

Class IV Antiarrhythmics MOA

Answer 2

Non-Dihydropyridine Calcium Channel Blockers

-Block L-type voltage gated Calcium channels in the heart thus block calcium current in the SA and AV nodes
(“L shaped nozzles on wall”)
(“Notes on music sheet”)

• Exert a greater effect on tissues that fire more frequently that use a calcium current

-non-dihydropyridine CCB’s prolong phase 4 of the nodal action potential 􏰀decreased pacemaker activity, prolonged conduction time and refractory period
(“pianist sliding up the keys”)

-non-dihydropyridine CCB’s decrease atrioventricular conduction

(“Disconnected bottom of heart shaped lamp”)

Question 3

Class IV Antiarrhythmics can treat …

Answer 3

-treat supraventricular arrhythmias (A.FIB with RVR)
(“Illuminated top of the heart shaped lamp”)

-useful in atrial fibrillation and flutter
(“tv showing Irregularly irregular signal”)

-prevents rapid ventricular response in A Fib and Flutter
(“heart shaped metronome on piano”)