Class II Antiarrhythmics

Question 1

Class II Antiarrhythmics are …

Answer 1

Beta Blockers
(“muted Beta Bugle”)

Non Selective

• *Proprano**lol
• *Sota**lol
• *Timo**lol
• *Nado**lol

Selective

“A-BEAM”

• *Acebuto**lol
• *Bisopro**lol
• *Esmo**lol
• *Ateno**lol
• *Metopro**lol

Question 2

Beta Blockers MOA
(“muted Beta Bugle”)

Answer 2

-blocking sympathetic input to SA and AV nodes
(“SA , AV Notes”)

-decrease cAMP , leads to closure of membrane calcium channels, preventing the upstroke of AV nodal action potential
(“Torn Band Camp poster”)
(“Crushed calci-yum ice cream cartons on the floor”)

-prolong phase 4 of the nodal action potential decreased pacemaker activity, prolonged conduction time and refractory period
(“Ella Fitzgerald sliding up the piano keys”)

-decrease atrioventricular conduction
(“disconnected bottom of heart shaped lamp”)

Question 3

Class II Antiarrhythmics can be used to treat …

Answer 3

-supraventricular arrhythmias (Afib and RVR)
(“upper part of heart shaped lamp is lit”)

-useful in atrial fibrillation (and flutter)
(“Irregularly irregular static signal”)

-prevent rapid ventricular response in atrial fibrillation and flutter-“rate control”
[does not fix the atrial fibrillation]
(“heart shaped metronome”)

Question 4

Acute supraventricular arrhythmias can be treated with …

Answer 4

IV Beta blokcer e.g. - Esmolol

(“poison ivy”)

Question 5

Class II Antiarrhythmics Side effects

Answer 5

-Beta blockers can cause heart block

• heart block manifests as a prolonged PR interval on EKG
  (“suited reporter interviewed by Public relations”)

(“louie’s hat shielding heart”)