Class III Antiarrhythmics

Question 1

Names of Class III Antiarrhytmics

Answer 1

-Amiodarone
(“tres AMIGOs”)

-Tilide suffix (blue chica holding “till i die” sign )

• DOFE tilide
• ​IBU tilide

​-Sotalol (“Soda on table”)

Question 2

Class III Antiarrhytmics MOA

Answer 2

-block K+ channels prolonging phase 2 and 3 of the cardiac action potential→prolonged refractory period
(“Singer pushing away the Banana curtain”)

-*_Amiodarone_* shares properties of **class I, II, III,** and **IV** antiarrhythmics.
(grafiiti on wall says "uno, dos, tres, quattro”)

-Sotalol is also a beta blocker
(“Muted beta bugle and soda bottles”)

Question 3

Class III Antiarrhytmics can be used to treat …

Answer 3

-treat both supraventricular arrhythmias and also ventricular arrhythmias
(“Heart candles illuminated on top and bottom”)

-treat atrial fibrillation and flutter
(“Irregularly irregular signal on TV”)

-can restore and maintain normal sinus rhythm in atrial fibrillation and flutter
(“green shirt old fart converting the signal using remote control “)

Question 4

Amiodarone Side Effects

Answer 4

-many neurologic side effects -tremor, ataxia, peripheral neuropathy, sleep disturbances
(“sombrero with Skulls”)

-can cause grey corneal deposits
(“singer with Gray sunglasses”)

-can cause hyper or hypo-thyroidism
(“band members wear Big and small bowties

-can cause pulmonary fibrosis
(“Fibrotic lung embroidery on singer’s blazer “)

-lung fibrosis causes restrictive lung diseases
(“singer has tight button in his blazer”)

-can induce heart failure
(“Trampled failing heart balloon”)

-can cause hypersensitivity hepatitis
(“Liver spot on cow”)

-can cause gray blue skin discoloration
(“Mariachi band wearing Grey blue outfits”)

-inhibits the cytochrome P450 - drugs like warfarin and statins may increase

(“Broken chrome bumper”)

Question 5

Sotalol , Dofetilide , Ibutilide (Also Amiodarone)
Side Effects

Answer 5

-can induce dose related torsade’s
(“twisted torsades streamer”)

(although all type III antiarrhythmics can widen the QT interval)

Question 6

which lab tests should be preformed when starting Amiodarone therapy ?

Answer 6

• *Pulmonary** Function Test
• *Thyroid** Function Test
• *Liver** Function Test