class III

Question 1

amiodarone

Answer 1

Action: inhibits K+ currents; prolonged repol time; conduction velocity unchanged
Use: ventricular arrhythmias, recurrent AFIB and A flutter; bypass mediated PVST
Side effect: has many serious side effects including pulmonary and thyroid; highly effective in tx of cases of recurrent AFIB or A flutter; merit close monitoring of the patient

Question 2

dronedarone

Answer 2

Action: inhibits K+ currents; prolonged repol time; conduction velocity unchanged
Use: ventricular arrhythmias, recurrent AFIB and A flutter; bypass mediated PVST
Side effect: has many serious side effects including pulmonary and thyroid; highly effective in tx of cases of recurrent AFIB or A flutter; merit close monitoring of the patient
note: amiodarone analog; has much shorter half life; no side effect with thyroid, still merits monitoring

Question 3

ibutilide

Answer 3

Action: inhibits K+ currents; prolonged repol time; conduction velocity unchanged
Use: ventricular arrhythmias, recurrent AFIB and A flutter; bypass mediated PVST
Side effect: has many serious side effects including pulmonary and thyroid; highly effective in tx of cases of recurrent AFIB or A flutter; merit close monitoring of the patient
note: more of a "pure" class III agent

Question 4

dofetilide

Answer 4

Action: inhibits K+ currents; prolonged repol time; conduction velocity unchanged
Use: ventricular arrhythmias, recurrent AFIB and A flutter; bypass mediated PVST
Side effect: has many serious side effects including pulmonary and thyroid; highly effective in tx of cases of recurrent AFIB or A flutter; merit close monitoring of the patient
note: more of a "pure" class III agent

Question 5

sotalol

Answer 5

Action: inhibits K+ currents; prolonged repol time; conduction velocity unchanged
Use: ventricular arrhythmias, recurrent AFIB and A flutter; bypass mediated PVST
Side effect: has many serious side effects including pulmonary and thyroid; highly effective in tx of cases of recurrent AFIB or A flutter; merit close monitoring of the patient
note: also has a beta blocker activity

Question 6

bretylium

Answer 6

Action: inhibits K+ currents; prolonged repol time; conduction velocity unchanged
Use: ventricular arrhythmias, recurrent AFIB and A flutter; bypass mediated PVST
Side effect: has many serious side effects including pulmonary and thyroid; highly effective in tx of cases of recurrent AFIB or A flutter; merit close monitoring of the patient
note: blocks the release of catecholamines from nerve after initial stimulation of release; rarely used as an antiarrhythmic