Class 8 Flashcards

1
Q

What is Sensory Receptor?

A

Structure that recognizes stimulus. Stimulus is detectable change in internal or external environment. Under appropriate circumstances, receptor can transduce
(convert) stimulus into nerve signal. These signals are then
carried into CNS to be analyzed.

May be specialized portion of neuronal membrane, a separate cell associated with neuron ending, or group of
such cells. Sometimes receptor & neuron itself are together referred to as receptor.

EACH SENSORY RESPONDS MOST READILY TO ONE PARTICULAR FORM OF ENERGY. THIS IS CALLED ITS ADEQUATE STIMULUS. Receptors also respond to forms of energy other than the adequate stimulus, but threshold for these nonspecific responses is much higher.

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2
Q

What is threshold?

A

Magnitude or intensity that must be exceeded for a certain
reaction or condition to occur.

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3
Q

Between stimulus & perception of the stimulus is a series of 4 complex electrochemical events. The nerve impulse consists of an _________________ and a _____________________.

A

• electrical event
• chemical event (the neurotransmitter)

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4
Q

What is Transduction?

A

Process by which stimuli are converted to action potentials (APs) by sensory receptors. This is typically done by first order neurons

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5
Q

What is Transmission?

A

Process by which nerve signals enter & ascend the CNS in various tracts. This is done by second order neurons

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6
Q

What is Modulation?

A

Process by which electrochemical activity from other ascending inputs for example, touch, or signals descending from brain (emotions) can increase or decrease sensory transmission. In this manner the intensity of sensory input to cerebral cortex can be controlled. Typically done by third order neurons

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7
Q

What is Perception?

A

Process which results in subjective feelings. It’s a
poorly understood combination of transduction, transmission, & modulation. Can be altered by many phenomena including sleep & emotions such as fear, rage, & depression. Perception of touch sensation delivered by someone touching your arm during a happy moment has quite different results than one that has been delivered in middle of an argument.

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8
Q

what is the Relationship between Sensory Receptors and Unipolar Neurons?

A

Unipolar neurons have only one structure extending from the soma. It branches into two axons.

All unipolar neurons are attached to some sort of sensory receptor.

All unipolar cell bodies form cluster called dorsal root ganglion at every level of spinal cord

Their peripheral axons enter dorsal horn at each level & on both sides of spinal cord.

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9
Q

Every receptor has a defined area in the _______________, over which it can receive input. This is called the ____________________.

A

• periphery
• receptive field

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10
Q

What is Spatial discrimination?

A

Ability to accurately locate site of stimulation & to detect that neighbouring stimuli are actually separate.

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11
Q

Tactile sensitivity depends in part on _____________________ & ______________________________ in a particular skin region.

A

• density of receptors
• size of the receptive fields

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12
Q

More sensitive areas have smaller fields and a ____________________________ of receptors.

A

• higher concentration

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13
Q

What is the The two-point threshold?

A

The two-point threshold is the minimal distance in which two separate stimuli can be distinguished as separate.

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14
Q

In different parts of the skin, the concentration of various sensory receptors changes & this accounts for varying abilities in _________________________ in different regions. For Eg, on the back, density of tactile receptors is greatly reduced, & spatial discrimination is relatively poor.

A

spatial discrimination

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15
Q

What are Normal thresholds for two-point discrimination?

A

Tips of fingers are 3mm, forearm is 4mm, centre of back is about 6-7mm.

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16
Q

Continuous monitoring of an unchanging, static situation is usually ________________. It is much more important to ______________________.

A

• wasteful
• note changes

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17
Q

The receptors that respond best to change are called?

A

Fast adapting receptors or phasic receptors, for example, olfactory receptors.

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18
Q

What is Adaptation?

A

Decrease in sensory receptor sensitivity during a long-
lasting stimulus.

19
Q

What are Phasic receptors?

A

Phasic receptors or fast adapting receptors are in part responsible for fact that we can cease paying attention to constant stimuli. Odor, touch, & temperature, for eg. adapt rapidly. Bathwater feels hotter when we first enter it.

20
Q

Receptors which continue to respond throughout duration of prolonged stimulus are termed _________________________ or ____________________________. In this way they convey information about the duration of the stimulus. An example of a tonic receptor is a nociceptor, or barorecepto

A

slow adapting or tonic receptors

21
Q

What are Mechanoreceptors?

A

Largest category of sensory receptors & respond to deformation in body part. This group includes haptic
receptors, receptors that are involved in contributing to perception of touch. Bulbs on receptors amplify stimulus, lowering threshold.

22
Q

What are Haptic receptors?

A

Receptors involved in perceptions of touch. These include:

  • Ruffini terminals (endings) detect skin stretch, deformation within joints They monitor slippage of objects along surface of skin, allowing modulation of grip on an object.
  • Pacinian corpuscles detect transient pressure & high-frequency vibration.
  • Merkel’s disks are slowly adapting receptors & Meissner’s corpuscles are rapidly adapting touch receptors.
  • C tactile fibres have been linked to pleasant touch & are most responsive during slow gentle stroking in hairy skin.

They enable you to perceive both when you are touching something & how long an object is touching your skin. You get an enormous amount of information about the texture of objects through your fingertips because ridges that make up your fingerprints are full of these sensitive mechanoreceptors.

23
Q

What are Nociceptors?

A

Receptors that detect noxious or potentially damaging
stimuli. Often called free nerve endings because unlike other receptors they are not surrounded by connective tissue.

The term nociceptors can also include afferent neuron attached to them. Nociceptors respond to stimuli that could potentially damage body, such as extreme heat or cold, pressure, pinching, and chemicals.

Warning signals are then passed along to brain. These signals often but not always result in pain perception. Therefore, A NOCICEPTORS IS NOT AN AKA FOT PAIN RECEPTOR.

24
Q

What is Nociception?

A

refers to signal arriving at CNS as result of stimulation
of nociceptors. It’s the physiological process by which body tissues are protected from damage.

Nociception & pain each can occur without the other.

25
Q

What is Neuropathic Pain ?

A

Neuropathic (neurogenic) pain implies damage to nervous system itself, due to disease or trauma.
For example, diabetic neuropathy is a common
serious complication of
diabetes.

A substantial proportionnof patients who endure pain, for eg, chronic low back pain, have no identifiable structural pathology capable of explaining the pain.

In other situations, there is often a mix of nociceptive & neuropathic pain.

26
Q

What is Referred Pain?

A

Pain perceived at a location other than site of the painful stimulus. In other words, your brain misperceives location of pain.

27
Q

What are Low Threshold Receptors?

A

These sensitive receptors are immediately activated by their adequate stimulus. They are generally sensing innocuous, everyday types of stimuli & convey all the kinds of afferent information that represent routine sensory functions.

28
Q

What are High Threshold Receptors?

A

These receptors have a higher activation threshold & are used to detect harm or potential for harm in their tissues. They are sensitive to a variety of chemicals, & to extremes of temperature & mechanical stress.

29
Q

What is Proprioception?

A

Ability to know where your body is in space without use of vision. Sensory receptor components include muscle spindles and Golgi tendon organs.

30
Q
  • What is muscle spindle?
A

Sensory receptor that monitors a change in length of muscle & how fast it is being stretched.

31
Q

What is Stretch reflex?

A

Stretch reflex is an involuntary muscular contraction in response to fast stretch of the muscle.

32
Q

What is a reflex?

A

A fast, predictable sequence of involuntary actions. Occurs in response to certain stimuli. Eg. is “Knee Jerk” Reflex.

33
Q

What are Reflex arcs?

A

Anatomic pathways having afferent & efferent components that carry out reflex responses.

34
Q

The basic components of a reflex arc are?

A

A receptor that transduces stimuli to APs. An afferent neuron (unipolar) that carries APs to Interneurons (The stretch reflex is the only monosynaptic reflex). Efferent neurons that carry APs to Effectors (muscles or glands)

35
Q

Reflexes form basis of all CNS motor activity. They occur at _______________ of the CNS. Important bodily functions such as respiration, digestion, posture, defensive movement, micturition, sexual function, and walking are controlled through reflexes.

A

all levels

36
Q

What are Muscle spindles?

A

Detect and communicate the following information to
CNS.

where body is in space how fast body limbs are moving

Muscle Spindles are fusiform in shape meaning they bulge in the middle & taper at both ends.

37
Q

What is a Extrafusal muscle fibre?

A

up to 40 mm. in length, moves body parts.

Extrafusal muscle fibres are ordinary skeletal muscles fibres.

38
Q

What is Intrafusal muscle fibre?

A

4-7 mm. in length, adjusts spindle firing threshold/sensitivity

Intrafusal muscle fibres are tiny because they only need to adjust distance between coils of la unipolar sensory fibres wrapped around them. This controls spindle sensitivity. Don’t move bones like extrafusal fibres. Found in greatest abundance in muscles capable of delicate, fine, contractile activity like in hand & foot, suboccipitals & trasnversospinalis group of muscles.

39
Q

Muscle Spindle have 3 main components?

A
  • Intrafusal muscle fibres
  • la sensory unipolar neuron wrapped around these intrafusal muscle fibres & carry nerve impulse from muscle spindle to CNS when stimulated. As a result, Ia sensory neurons send nerve signal to CNS providing the “being stretched & how fast” information.
  • Connective Tissue encapsulating sensory receptor
40
Q

Extrafusal & Intrafusal fibres both contain ________ & _________ & can contract (shorten)

A

actin & myosin

41
Q

If the Extrafusal fibres are being stretched then the much smaller Intrafusal fibres of the muscle spindle within them are ________________________.

A

also being stretched

42
Q

What are Alpha Motor Neurons?

A

Motor neurons that innervate extrafusal muscle fibers.

43
Q

What is Reciprocal Inhibition?

A

Eg. Hamstrings are simultaneously inhibited as
quadriceps receives order to contract. This is simultaneous inhibition is referred to as reciprocal inhibition. This happens during any muscle concentric contraction.