Class 6 Deck 2 Flashcards

1
Q

Inamrinone is what type of drug? and what does it do?

A
  • P.D.E. Inhibitors

- increase SV and CO and Decreases SVR and PVR after CABG

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2
Q

How does inamrinone compare to dobutamine?

A

-More effective with less complications when separating from CPB

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3
Q

How does inamrinone compare to Epi?

A

-With poor LV function, it is as effective Epi, but they to work better together

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4
Q

What are the adverse reaction of inamrinone?

A
  • Thromocytopenia
  • ↑ LFTs
  • Arrhythmias
  • Intrapulmmonary shunting
  • Decreased PaO2
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5
Q

What is milrinone? and how does it compare to inamrinone?

A
  • P.D.E. Inhibitors (inotropic and vasodilator)

- 15-20x more potent than inamrinone w/o the thrombocytopenia

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6
Q

What is the antidote for Beta-blocker OD?

A

Glucagon

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7
Q

Glucagon use is limited by what?

A
  • N/V
  • ↑ blood sugar
  • ↑ coronary and pulmonary vascular resistance
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8
Q

Where is BNP synthesized and where is it stored? When is it released?

A
  • Synthesized in atrium = released when over distended

- Stored in brain = excreted with venous congestion

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9
Q

What 7 things does BNP do?

A
  • Sodium excretion
  • Suppress RAA Axis
  • Lower sympathetic tone
  • Lower vagal threshold
  • Diuresis
  • Vasodilate
  • Inhibit vasopressin
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10
Q

How does neseritide work and when is it used?

A
  • Stimulates cGMP = vascular smooth muscle relax

- Used in decompensated CHF

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11
Q

What is digoxin and what does it do to the heart?

A
  • Cardiac glycoside
  • Positive inotrope (Ca binds to Troponin)
  • Negative dromotrope
  • Negative chromotrope
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12
Q

What is digoxins mechanism of action?

A
  • Inhibits Na-K ATPase which increases intracellular Na and Ca
  • Increase LV shortening and EF
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13
Q

What are the uses for digoxin?

A
  • Mild to moderate heart failure (w/diuretic and ACEI)

- Control chronic AFib

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14
Q

What are the 3 indirect actions digoxin has on the CV system?

A
  • Vagomimetic effect (Slow HR w/ ↓ conduction of AV node)
  • Baroreceptor sensitization
  • Toxic effect on CNS (↑ sympathetic outflow)
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15
Q

What blood level is digoxin considered toxic?

A

> 3

  • If treating CHF <3
  • If treating AFib treat to results
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16
Q

What are the signs and symptoms of digoxin toxicity?

A
  • Early = Anorexia and N/V
  • PVCs
  • Atrial tach w/ block
  • Mobitz type 2
  • VFib = most frequent cause of death
17
Q

How to treat digoxin toxicity?

A
  • Supplement K, Mag
  • Correct hypoxemia
  • Phenyotoin to correct Ventricular dysrhythmias
  • Atropine to treat brady
  • Beta blocker to suppress increased automaticity
  • Digibind
  • Temp Pacing
18
Q

What are the catecholamine complications?

A
  • Local tissue ischemia
  • ↑ Myocardial work and O2 consumption
  • ↑ cardiac arrhythmias
  • Alter electrolytes and CO distribution
  • Activate Coags
  • Enhance lipolysis and gluconeogensis
  • Override microvascular control mechanisms
19
Q

What are the potential complications with PDE inhibitors and Beta Agonists?

A

-Intrapulmonary shunt after CABG

20
Q

What are the steps in the theraputic plan for Low CO?

A
  • Optimize HR and Rhythm
  • Optimize preload (increase intravascular volume)
  • Administer arteriole dilator to decrease SV (optimize afterload)
  • Low BP = Add inotrope
21
Q

What is the initial drug selection for pulmonary or systemic HTN?

A
  • Something to dilate
  • Dobutamine
  • inamrinone / milrinone
  • Isoproterenol
22
Q

What is the initial drug selection for Low SVR?

A
  • Need to tighten up
  • NorEpi
  • Dopamine
  • Epi
23
Q

What is the initial drug selection for normal PVR and SVR?

A
  • Dopamine

- Epi

24
Q

What is the initial drug selection for tachycardia?

A
  • Inamrinone / milrinone
  • Calcium
  • Nor Epi
  • Epi
25
Q

To treat Myocardial Ischemia, Decrease BP and SVR, Normal CO and no heart failure what would you treat with?

A
  • Vasoconstrictor (phenylepherine)

- NTG

26
Q

Why would one Reserve vasoconstrictors for patients with small hearts?

A

-They are preload sensitive and afterload insensitive

27
Q

What does a heart need with PCWP <18

A

Volume expanded