Class 4 Deck 1 Flashcards
Name the 3 sites of actions in which a vasodilator can be classified.
- Arterial dialator (resistance circulation)
- Venodialators (Capacitance circulation)
- Balanced
Give and example of an Arterial dialator, venodialator, and a balanced vasodialator.
- Arterial = Hydralizine, ACE, Nicardipine
- Balanced = Nitroprusside
- Venodialator = Nitroglycerine
Pure arteriole dilator causes minimal effect on what?
-Preload
Balanced vasodilator (SNP) decreases what 2 things?
-Afterload and preload
What drug may be the only pure pulmonary vasodilator?
-Nitrous Oxide
PGE1 is excellent pulmonary vasodilator, but also causes systemic?
Hypotension
What drug may improve coronary circulation?
-NTG
Which drug will increase coronary perfusion pressure?
-Nitroglycerine
In presence of coronary steal, what drug will shunt blood away from ischemic areas and what drug will direct more blood to the ischemic area?
- SNP is bad during MI
- Nitroglycerine is good during MI
How does nitroglycerine treat myocardial ischemia?
- Coronary vasodialtor / Improved collateral flow
- Venodialation decrease venous return and filing pressure
How does CCB treat myocardial ischemia?
- coronary and systemic vasodialators
- Decrease afterload
- Treats coronary vasospasm
Why is SNP non-useful with myocardial ischemia?
- Reduces ventricular filling pressure
- Coronary steal
What 2 drugs use NO, in order to produce their effects? and how do they work?
- SNP (spontaneously generates NO)
- NTG (Requires a cofactor to release NO in smooth muscle)
How does NO (therefore SNP and NTG) produce vasodialation?
- Forms cGMP
- cGMP inhibits calcium entry into smooth muscle cells, which produces vasodialation
What are the effects of NO?
- Vasodilator
- Relax other smooth muscle
- Increase blood flow to the lung
- Decreases pulmonary vascular resistance