Class 4: PPP-Theisen

Question 1

Rate-limiting step in PPP?

Answer 1

Initial step:

glucose-6-phosphate dehydrogenase

Question 2

What is the substrate for glucose-6-dehydrogenase?

Answer 2

Glucose-6-phosphate

Question 3

X linked recessive disease d/t deficiency in levels of NADPH

Altered G6PD produces low levels of NADPH = low levels of reduced glutathione in RBCs = not healthy RBC cell membranes

=hemolytic anemia

Answer 3

Favism

Question 4

G6PD deficiency coincides w/ malaria. Why do you think?

Answer 4

May impart some resistance to malaria.

Question 5

Glu-6-P converted by G6PD then to ribulose-5-P is which phase?

Answer 5

Oxidative

Question 6

Ribulose 5 P is needed for

Answer 6

DNA/RNA synthesis

Question 7

Ribose-5-phosphate is needed, but end up getting some NADPH also

Ultimately need nucleotide synthesis (cell division) of some regard

Answer 7

Mode 1

Question 8

The cell needs BOTH NADPH and ribose-5-phosphate

Answer 8

Mode 2

Question 9

NADPH is needed but end up picking up some Ribose-5-P also

Answer 9

Mode 3

Question 10

When the cell needs BOTH NADPH and ATP.

Answer 10

Mode 4

Question 11

Males are more likely to get favism (G6PD deficiency). Why?

Answer 11

It is an X-linked recessive disease