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Hard stuff to remember > CLASP sepsis > Flashcards

CLASP sepsis Flashcards

1
Q

examples of alpha haemolytic strep

A
  • strep. pneumonia

- strep. viridans

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2
Q

examples of group A beta haemolytic strep

A

-strep pyrogenes

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3
Q

examples of group B beta haemolytic strep

A

-strep agalactiae

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4
Q

examples of gamma haemolytic strep

A

-enteroccoccus

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5
Q

coagulase positive staph

A

-staph aureus

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6
Q

coagulase negative staph

A

-staph epidermidis

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7
Q

club shaped gram positive bacilli

A
  • corynebacterium
  • listeria
  • mycobacterium (acid fast)
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8
Q

spore baring/large bacilli

A
  • bacillus cereus

- clostridium difficile

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9
Q

gram neg aerobic bacilli which ferment lactose

A
  • E.Coli
  • klebsiella
  • enterobacter (THIS IS DIFFERENT FROM GRAM POS ENTEROCOCCUS)
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10
Q

gram neg aerobic bacilli which don’t ferment lactose

A
  • proteus
  • salmonella
  • shigella
  • pseudomonas
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11
Q

gram neg anaerobic bacilli

A
  • legionella
  • pseudomonas
  • bacteroides
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12
Q

gram neg cocci

A
  • neisseria gonorrhoea (diplococci)

- neisseria meningitidis

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13
Q

gram neg small aerobic bacilli

A
  • haemophilus influenzae

- pertussus

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14
Q

gram neg curved bacilli

A

-campylobacter

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15
Q

gram neg spiral bacilli

A

-H. pylori

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16
Q

what is the sepsis 6?

A
  • take cultures
  • take urine/catheterise
  • take lactate
  • give O2
  • give fluid challenge
  • give IV antibiotics
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17
Q

CAP mild and severe treatments

A

mild: amoxicillin (5 days)
severe: Co-amoxiclav + doxycycline

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18
Q

CAP penicillin allergy

A

mild: doxycycline
severe: levofloxacin

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19
Q

HAP mild and severe treatments

A

mild: amoxicillin
severe: amoxicillin + gentamicin (IV)

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20
Q

HAP penicillin allergy

A

mild: doxycycline
severe: co-trimoxazole + clarithromycin

21
Q

C diff non-severe treatment

A

metronidazole

22
Q

C diff severe treatment

A

vancomycin + metronidazole

23
Q

peritonitis/biliary tract (ascending cholangitis)/intra-abdominal treatment

A
  • IV amoxicillin + metronidazole + gentamicin

- step down to PO co-trim and metro

24
Q

Complicated UTI/ pyelonephritis/Urosepsis treatment

A
  • IV amoxicillin + gentamicin

- step down to co-trim

25
Q

uncomplicated lower UTI (female/uncatheterised male UTI) treatments

A
  • Nitrofurantoin OR

- trimethoprim

26
Q

sepsis definition

A
  • dysregulated/exaggerated host response to infection

- clinical suspicion of infection + NEWS greater than 5

27
Q

septic shock definition

A
  • circulatory and cellular and metabolic dysfunction

- persistant hypertension and lactate over 2 despite adequate fluid resuscitation

28
Q

what should you do if you discover strep galoliticus infection

A
  • colonoscopy

- look for colon cancer

29
Q

V. atypical cause of endocarditis

A

E.Coli

30
Q

what are the four C antibiotics

A
  1. Co-amoxiclav (ortho cover)
  2. clindamycin
  3. cephalosporins (pregnant/kids)
  4. ciprofloxacin (all quinolones don’t forget levofloxacin!!)
31
Q

What does bradykinin do?

A

-pain at site of infection

32
Q

what does complement do?

A
  • neutralise pathogens
  • mobilise WBC
  • amplify host response
33
Q

what does thrombin do?

A
  • forms clots

- produces NO (vasodilatation)

34
Q

which IL associated with sepsis ?

A

-IL-6

35
Q

why is lactate significant?

A
  • associated with tissue hypoxia

- acidic (anaerobic respiration)

36
Q

side effect of fluclox/co-amox

A

-cholestatic jaundice

37
Q

side effect of quinolones e.g. levofloxacin

A
  • Q-T changes
  • convulsions/ decrease in epileptic control
  • tendonitis
38
Q

side effects of aminoglycosides e.g. gentamicin

A
  • nephrotoxicity (tubular necrosis)

- ototoxicity

39
Q

what should not be done while taking metronidazole?

A

-DRINK!!

40
Q

what other antibiotics should not be given to penicillin allergic?

A
  • cephalosporins
  • carbepanems
  • ?aztreonam
41
Q

what is good for toxin producing infections e.g. PVL, group A strep

A

-clindamycin

42
Q

which antibiotics cover pseudomanas?

A
  • ciprofloxacin

- gentamicin

43
Q

treatment for legionella?

A

-clarithromycin

44
Q

good antibiotic for enterococci

A

-amoxicillin

45
Q

Endocarditis native valve subacute treatment

A

IV amoxicillin + gentamicin

46
Q

endocarditis native valve acute/severe

A

IV fluclox

47
Q

prosthetic valve/suspected MRSA endocarditis

A

IV vancomycin + IV gentamicin (+ oral rifampicin when therapeutic doses of others reached)

48
Q

open fracture/ortho surgery prophylaxis

A

Co-amoxiclav (co-trim +metronidazole if penicillin allergic)

Hard stuff to remember (10 decks)

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