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CLASP sepsis Flashcards

1
Q

examples of alpha haemolytic strep

A
  • strep. pneumonia

- strep. viridans

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2
Q

examples of group A beta haemolytic strep

A

-strep pyrogenes

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3
Q

examples of group B beta haemolytic strep

A

-strep agalactiae

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4
Q

examples of gamma haemolytic strep

A

-enteroccoccus

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5
Q

coagulase positive staph

A

-staph aureus

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6
Q

coagulase negative staph

A

-staph epidermidis

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7
Q

club shaped gram positive bacilli

A
  • corynebacterium
  • listeria
  • mycobacterium (acid fast)
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8
Q

spore baring/large bacilli

A
  • bacillus cereus

- clostridium difficile

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9
Q

gram neg aerobic bacilli which ferment lactose

A
  • E.Coli
  • klebsiella
  • enterobacter (THIS IS DIFFERENT FROM GRAM POS ENTEROCOCCUS)
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10
Q

gram neg aerobic bacilli which don’t ferment lactose

A
  • proteus
  • salmonella
  • shigella
  • pseudomonas
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11
Q

gram neg anaerobic bacilli

A
  • legionella
  • pseudomonas
  • bacteroides
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12
Q

gram neg cocci

A
  • neisseria gonorrhoea (diplococci)

- neisseria meningitidis

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13
Q

gram neg small aerobic bacilli

A
  • haemophilus influenzae

- pertussus

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14
Q

gram neg curved bacilli

A

-campylobacter

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15
Q

gram neg spiral bacilli

A

-H. pylori

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16
Q

what is the sepsis 6?

A
  • take cultures
  • take urine/catheterise
  • take lactate
  • give O2
  • give fluid challenge
  • give IV antibiotics
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17
Q

CAP mild and severe treatments

A

mild: amoxicillin (5 days)
severe: Co-amoxiclav + doxycycline

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18
Q

CAP penicillin allergy

A

mild: doxycycline
severe: levofloxacin

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19
Q

HAP mild and severe treatments

A

mild: amoxicillin
severe: amoxicillin + gentamicin (IV)

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20
Q

HAP penicillin allergy

A

mild: doxycycline
severe: co-trimoxazole + clarithromycin

21
Q

C diff non-severe treatment

A

metronidazole

22
Q

C diff severe treatment

A

vancomycin + metronidazole

23
Q

peritonitis/biliary tract (ascending cholangitis)/intra-abdominal treatment

A
  • IV amoxicillin + metronidazole + gentamicin

- step down to PO co-trim and metro

24
Q

Complicated UTI/ pyelonephritis/Urosepsis treatment

A
  • IV amoxicillin + gentamicin

- step down to co-trim

25
uncomplicated lower UTI (female/uncatheterised male UTI) treatments
- Nitrofurantoin OR | - trimethoprim
26
sepsis definition
- dysregulated/exaggerated host response to infection | - clinical suspicion of infection + NEWS greater than 5
27
septic shock definition
- circulatory and cellular and metabolic dysfunction | - persistant hypertension and lactate over 2 despite adequate fluid resuscitation
28
what should you do if you discover strep galoliticus infection
- colonoscopy | - look for colon cancer
29
V. atypical cause of endocarditis
E.Coli
30
what are the four C antibiotics
1. Co-amoxiclav (ortho cover) 2. clindamycin 3. cephalosporins (pregnant/kids) 4. ciprofloxacin (all quinolones don't forget levofloxacin!!)
31
What does bradykinin do?
-pain at site of infection
32
what does complement do?
- neutralise pathogens - mobilise WBC - amplify host response
33
what does thrombin do?
- forms clots | - produces NO (vasodilatation)
34
which IL associated with sepsis ?
-IL-6
35
why is lactate significant?
- associated with tissue hypoxia | - acidic (anaerobic respiration)
36
side effect of fluclox/co-amox
-cholestatic jaundice
37
side effect of quinolones e.g. levofloxacin
- Q-T changes - convulsions/ decrease in epileptic control - tendonitis
38
side effects of aminoglycosides e.g. gentamicin
- nephrotoxicity (tubular necrosis) | - ototoxicity
39
what should not be done while taking metronidazole?
-DRINK!!
40
what other antibiotics should not be given to penicillin allergic?
- cephalosporins - carbepanems - ?aztreonam
41
what is good for toxin producing infections e.g. PVL, group A strep
-clindamycin
42
which antibiotics cover pseudomanas?
- ciprofloxacin | - gentamicin
43
treatment for legionella?
-clarithromycin
44
good antibiotic for enterococci
-amoxicillin
45
Endocarditis native valve subacute treatment
IV amoxicillin + gentamicin
46
endocarditis native valve acute/severe
IV fluclox
47
prosthetic valve/suspected MRSA endocarditis
IV vancomycin + IV gentamicin (+ oral rifampicin when therapeutic doses of others reached)
48
open fracture/ortho surgery prophylaxis
Co-amoxiclav (co-trim +metronidazole if penicillin allergic)

Hard stuff to remember (10 decks)

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