CKD Therapeutics

Question 1

lab values for Hb, TSAT, Ferritin, MCV, RDW

Answer 1

Hb: 12g/dL for females; 13g/dL for males
TSAT: 20-30%
Ferritin: 200-500
MCV: 80-96 um3
RDW: 11.5-14.5%

Question 2

Adjusted BW equation

Answer 2

AdjBW= IBW + 0.4(ABW-IBW)
-use if 130% of their IBW

Question 3

Calcium Phosphate Binders

Answer 3

Calcium Carbonate (Tums)
Calcium acetate (PhosLo)
SE: Constipation

Question 4

non-calcium Phosphate Binders

Answer 4

Sevelamer Carbonate (Renvela)
-decreases LDL & Uric Acid
Lanthanum Carbonate (Fosrenol)
-can bind to Phos in acidic environments
Sucroferric oxyhydroxide (Velphoro)
-no effect on iron stores
Auryxia (ferric citrate)
-for CKD patients on dialysis, some iron is absorbed

Question 5

Activated Vitamin D medications

Answer 5

calcitriol (Rocaltrol and Calcijex)
-can cause hypercalcemia
Paricalcitol (Zemplar)
Doxercalciferol (Hectorol)
-prodrug must be activated by liver

Question 6

Inactivated Vitamin D medications

Answer 6

Egrocalciferol (Calciferol)
Cholecalciferol

Question 7

Calcimimetics

Answer 7

Cinacalcet (Sensipar)
Etelcalcetide (Parsabiv)
-contraindicated in hypocalcemia if Ca is <7.5 mg/dL

Question 8

Oral Iron medications

Answer 8

Ferrous Sulfate (Proferrin Es, Proferrin Forte)

Question 9

IV Iron medications

Answer 9

Iron Dextran (InFed, Dexferrum)
-requires a test dose

Iron Sucrose (Venofer)
-can be used for non-dialysis patients

Ferumoxytol (Feraheme)
-interferes with MRI machines for 3 months

Triferic (Ferric pyrophosphate citrate)
-can be added to dialysis bag itself

Question 10

ESA medications

Answer 10

Recombinant Human Erythropoietin (Epotein alfa)
Darbepoetin alfa (Aranesp)
Methoxy polyethylene glycol-epotein beta (Mircera)
-SE is HTN

Question 11

HIF-PHI medication

Answer 11

Daprodustat (Jesduvroq)
-metabolized by liver