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Pharmacy School Fall P2 > ANTICOAGGGGGGG > Flashcards

ANTICOAGGGGGGG Flashcards

1
Q

What medication falsely elevates INR?

A

Argatroban
-IV direct thrombin inhibitor
-overlap with warfarin until INR is below(or equal to) 4

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2
Q

What medication dosage adjustment is based on Hepatic function?

A

Argatroban

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3
Q

What medication should NOT be used prophylactically with low body weight (<50kg)?

A

Fondaparinux (SubQ)
-do not use if CrCl <30mL/min
-used in HIT

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4
Q

Is monitoring required for Enoxaparin?

A

No
-consider in special populations (anti Xa levels)

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5
Q

is monitoring required for unfractionated Heparin?

A

Yes
-aPTT goal is 1.5-2.5x time control

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6
Q

approved indications for Dabigatran (Pradaxa)

A

postoperative prophylaxis (HIP ONLY); afib; DVT/PE treatment

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7
Q

approved indications for Rivaroxaban (Xarelto)

A

postoperative prophylaxis, afib; DVT/PE treatment, secondary prevention of recurrent DVT/PE, VTE prophylaxis

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8
Q

approved indications for Apixaban

A

postoperative prophylaxis; afib; DVT/PE; secondary prevention of recurrent DVT/PE

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9
Q

approved indications for Edoxaban

A

afib; DVT/PE treatment

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10
Q

what do CYP2C9 mutations mean for the Warfarin dose requirement?

A

lower dose requirement

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11
Q

what do 1639A mutations mean for the Warfarin dose requirement?

A

increased warfarin sensitivity
-lower dose requirement

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12
Q

what do 1639G mutations mean for the Warfarin dose requirement?

A

increased warfarin resistance
-higher dose requirement

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13
Q

What is the reversal agent for UFH and LMWH?

A

Protamine Sulfate

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14
Q

What is the reversal agent for dabigatran?

A

Idarucizumab

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15
Q

What is the reversal agent for Apixaban and Rivaroxaban?

A

Andexanet alfa (Andrexxa)

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16
Q

What is the reversal agent for Warfarin?

A

Prothrombin Complex Concentrate (PCC)<Fresh Frozen Plasma (FFP) < IV Vitamin K < PO Vitamin K (slowest)

17
Q

What are the factors for the CHADsVASc score?

A

CHF -1
Age 75+ -2
stroke/TIA -2
HTN -1
Vascular disease (prior MI, PAD, aortic plaque) -1
age 65-74 -1
female -1
diabetes -1

18
Q

What are the direct thrombin inhibitor medications?

A

Dabigatran (Pradaxa)

19
Q

What are the factor Xa inhibitors?

A

Rivaroxaban (Xarelto)
Apixaban (Eliquis)
Edoxaban (Savaysa)

20
Q

What medication is renal cosiderations in SCr not CrCl?

A

Apixaban

21
Q

For DVT/PE treatment, what must be done with Dabigatran and Edoxaban?

A

-requires 5-10 days parenteral anticoagulation (enoxaparin) before starting them

Pharmacy School Fall P2 (13 decks)

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