CKD Flashcards
How is CKD defined?
damage to kidneys for decrease in function x3 mo
top 3 causes of CKD
DM
HTN
NSAIDs
S/S of CKD
Fatigue HTN \+/- Urination Edema H2O/Electrolyte imbalances Hematuria/Proteinuria SCr/BUN Decrease GFR
GFR for... Stage 1 Stage 2 Stage 3a Stage 3b Stage 4 Stage 5
Stage 1: >90 Stage 2: 90-60 Stage 3a: 59-45 Stage 3b: 44-30 Stage 4: 29-15 Stage 5: <15
Describe…
Stage 1/2 CKD
Stage 3/4 CKD
Stage 5 CKD
Stage 1/2 CKD: structural abnormalities with preserved renal fxn
Stage 3/4 CKD: reduced function, symptomatic
Stage 5 CKD: ESRD
What is included in the W/U for CKD?
GFR: <60 Microalbuminuria (proteinuria) UA (broad waxy casts) Serum Electrolytes High BUN/SCr Abnormal: Hgb, Hct, low EPO, dysmorphic RBC
How do you Tx CKD?
ACEI/ARB/DI Managecomorbidities (DM, HTN, Smoking) Maintain Hgb Dietary management - restrict protein - Ca/Vit D supplement - limit: H2O, Na, K, Ph - No NSAIDs Hemodialysis (peritoneal) Kidney Transplant
What are some systemic effects of CKD
Anemia HTN Prolonged bleeding Dermatologic manifestations Electrolyte manifestations Bone manifestations
How do you dx glomerulonephirtis
Renal bx
UA (dysmorphic RBC, RBC casts)
Proteinuria
high BUN/SCr
what are examples of Nephrotic dzs
Minimal Change dz
Focal segmental GS
Membranous GN
What are examples of Nephritic
Post infectious GN
Crescentic GN
IgA
Nephrotic syndrome Urine casts: \_\_\_\_\_ Proteinuria: \_\_\_\_\_ Hematuria: \_\_\_\_\_\_ Clinical features: \_\_\_\_
Urine casts: fatty casts
Proteinuria: >3.5 g/day
Hematuria: +/-
Clinical features: Generalized edema, periorbital edema, HTN
Nephritic syndrome Urine casts: \_\_\_\_\_ Proteinuria: \_\_\_\_\_ Hematuria: \_\_\_\_\_\_ Clinical features: \_\_\_\_
Urine casts: RBC casts
Proteinuria: <3.5 g/day
Hematuria: ++ (coca-cola urine)
Clinical features: HTN, Edema
what can cause Acid/Base issues?
M: Methanol (Metformin) U: Uremia D: Diabetic Ketoacidosis P: Paraldeyhde I: Iron, Isoniazid (intoxication) L: lactic acid E: Ethylene glycol S: Salicylates
what causes alcoholic ketoacidosis?
- Labs?
- Tx?
poor nutritional status w/ abrupt EtOH cessation or binge drinking
Labs: low K/Na+
Fomepizole