Citric Acid Cycle Flashcards

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1
Q

Where does CAC occur?

A

It occurs in the mitochondrial matrix.

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2
Q

How is acetyl CoA made from pyruvate?

A

Through pyruvate dehydrogenase. It gets decarboxylated and oxidised before getting the CoA part added. The decarboxylation part releases two protons which can make more ATP.

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3
Q

How is pyruvate dehydrogenase regulated?

A

It is regulated by its immediate products and by ATP depending on the needs of the cell.

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4
Q

What are two other points of control?

A

Isocitrate dehydrogenase is allosterically controlled through ATP and NADH concentrations.
Alpha ketoglutarate dehydrogenase is also regulated by ATP and NADH and any excess switches it’s use to amino acids

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