Citric acid cycle

Question 1

acetyl coA + oxaloacetate + H20–> citrate + coA + H+

Answer 1

citrate synthetase
acetyl coA
condensation/hydrolysis

Question 2

citrate–>cis-aconitate + H20

Answer 2

aconitase
Fe/S
dehydration

Question 3

cis-aconitate + H20–> isocitrate

Answer 3

acointase
Fe/S
hydration

Question 4

isocittrate + NAD+–> alpha ketoglutarate + CO2 + NADH

Answer 4

alpha ketoglutarate dehydrogenase complex
cofactors and prosthestic groups: NAD+, CoA. TPP, Lipoic Acid, FAD
oxidation and decarboxylation

Question 5

succinyl coA + Pi + GDP—>succinate + GTP + CoA

Answer 5

succinyl coA synthetase
CoA
substrate-level phosphorylation

Question 6

succinate + FAD (enzyme bound)–>fumarate + FADH2 (enzyme-bound)

Answer 6

succinate dehydrogenase
FAD
oxidation

Question 7

Fumarate + H20–> malate

Answer 7

fumarase
none
hydration

Question 8

Malate + NAD–> oxaloacetate + NADH + H

Answer 8

malate dehydrogenase
NAD
oxidation

Question 9

acetyl CoA + oxaloacetate + H20

Answer 9

citrate + CoA + H+

Question 10

citrate

Answer 10

cis aconitate + H20

Question 11

cis-aconittate + H20

Answer 11

isocitrate

Question 12

isocitrate + NAD

Answer 12

alpha-ketogluterate + CO2 + NADH

Question 13

alpha keto-glutarate + NAD + CoA

Answer 13

succinly coA + CO2 + NADH

Question 14

succinly coA + Pi + GDP

Answer 14

succinate + GTP + CoA

Question 15

succinate + FAD

Answer 15

fumarate + FADH2

Question 16

fumarate + H20

Answer 16

malate

Question 17

malate + NAD–>

Answer 17

oxaloacetate + NADH + H+

Question 18

site of action of arsenic poison is ___. part of the ___ complex

Answer 18

dihydrolipamaides ; pyruvate dehydorgenase