Citric Acid Cycle Flashcards

1
Q

Citric acid cycle produces reduced coenzymes

A

-NADH
- FADH2
- one ATP directly.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

(1-8) Reactions in citric acid cyle

A

1: Condensation
2: Isomerization
3: Oxidative decarboxylation
4: Oxidative decarboxylation
5: hydrolysis
6: dehydration
7: hydration
8: dehydrogenation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Product in reaction 1

A

Citrate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Product in reaction 2

A

Isocitrate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Product in reaction 3

A

a-Ketoglutarate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Product in reaction 4

A

Succinyl CoA, NADH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Product in reaction 5

A

Succinate, GTP, CoA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Product in reaction 6

A

Fumarate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Product in reaction 7

A

Malate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Product in reaction 8

A

Oxaloacetate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Isomerizes to isocitrate.

A

Citrate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Has a tertiary —OH group converted to a secondary—OH in isocitrate that can be oxidized.

A

Citrate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Undergoes decarboxylation (carbon removed as CO2)

A

Isocitrate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

▪ Undergoes decarboxylation to form succinyl CoA.
▪ Produces a 4-carbon compound that bonds to CoA.
▪ Provides H+ and 2e−
to reduce NAD+ to NADH.

A

(alpha)a-Ketoglutarate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Undergoes breaking of the thioester bond

A

Succinyl CoA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Provides energy to add phosphate to GDP and form GTP, a highenergy compound.

A

Succinyl CoA

17
Q

▪ Undergoes dehydrogenation.
▪ Loses two H and forms a double bond.
▪ Provides 2H to reduce FAD to FADH2.

A

Succinate

18
Q

▪ Undergoes hydration.
▪ Adds water to the double bond.
▪ Is converted to malate

A

Fumarate

19
Q

▪ Undergoes dehydrogenation.
▪ Forms oxaloacetate with a C=O double bond.
▪ Provides 2H that reduce NAD+ to NADH + H+

A

Malate

20
Q

Products formed in one turn of the citric acid cycle

A
  • 2 CO2
  • 3 NADH
  • 1 FADH2
  • 1 GTP
21
Q

enzyme in reaction 1

A

Citrate synthase

22
Q

enzyme in reaction 2

A

Aconitase

23
Q

enzyme in reaction 3

A

Isocitrate dehydrogenase

24
Q

enzyme in reaction 4

A

a-ketoglutarate dehydrogenase

25
Q

enzyme in reaction 5

A

Succinyl-CoA synthetase

26
Q

enzyme in reaction 6

A

Succinic dehydrogenase

27
Q

enzyme in reaction 7

A

Fumarase

28
Q

enzyme in reaction 8

A

Malate dehydrogenase

29
Q

The reaction rate for citrict acid cycle:
Increases when low levels of ____ or ____ activate ______ ______.

A
  • ATP or NAD+
  • isocitrate
    dehydrogenase.
30
Q

Decreases when high levels of ___ __ ___ inhibit ____ _____ (first step in cycle).

A
  • ATP or NADH
  • citrate synthetase