Citrate Cycle Steps Flashcards
Step 1
condensation of oxaloacetate and acetyl-CoA by citrate synthase to form citrate
Step 2
Isomerization of citrate by aconitase to form isocitrate
Step 3
Oxidative decarboxylation of isocitrate by isocitrate dehydrogenase to form alpha-ketogluterate, CO2, and NADH
Step 4
Oxidative decarboxylation of alpha-ketogluterate by alpha-ketogluterate dehydrogenase to form succinyl-CoA, CO2, and NADH
Step 5
conversion of succinyl-CoA to succinate by succinyl-CoA synthase in a substrate level phosphorylation reaction that generates GTP
Step 6
Oxidation of succinate by succinate dehydrogenase to form fumerate
Step 7
Hydration of fumerate by fumerase to form malate
Step 8
Oxidation of malate by malate dehyrogenase to form oxaloacetate