CIS 3 Flashcards

1
Q

Which of the following is most used to diagnose primary coagulopathies (embolism)?

A

NOT PTT and PT: they will measure clotting time.

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2
Q

for bleeding disorders, what do we measur/

A

PT
aPTT
CBC
platelet function testing

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3
Q

For thrombotic diosders, what do we measure?

A

Genetic testing
APCR
Endogenous anticoagulant levels

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4
Q

should we ever pick bleeding time as a test to measure?

A

no

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5
Q

Venous thrombosis ( ___ thrombus)

charactistic?

A

red

swollen and painful, warm

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6
Q

o Name the artery most likely to be empolized by a red thrombus

A

pulmonary A.

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7
Q

if limb is VERY pain and pulseless, what should we assume?

A

arterial thrombosis (white thrombosis?

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8
Q

Characteristics of arterial thrombosis?

A

Cyanotic, because O2 is not arriving

Platelet rich, occur in high shear stress

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9
Q

How can we test if someone has a problem with fibrinogen?

A

• Thrombin

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10
Q

Thrombin time: adding thrombin to a blood sample will bypass all other clotting factors and force a clot, unless ____ is deficient

A

fibrinogen

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11
Q

Most likely cause massive bleeding

A

fluid loss => hypovolemic shock

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12
Q

What would we most likely see in septic shock?

A

low blood pressure and increased HR to compensate

bc one of the first things to happen is vasodilationd d/t inflammation => lower BP. Endthelial spaces widen and fluid leaks out=> further lower BP

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13
Q

Physical exams of septic shock would show:

A
soft tissue edema
wet lungs 
leukocytosis (inflammatory response)
hyPOtension
necotic toes
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14
Q

Shock occurs when ________________. Injury is only reversible in the beginning. 3 types

A

not enough CO or circulating blood volume to supply tissues, causing hypoxia

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15
Q

Cardiogenic shock: damage to ________ causes low CO

A

myocardial pump

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16
Q

Hypovolemic shock:_______ causes low CO

A

low blood volume (V/D/fkuid loss, burns)

17
Q

Septic shock is d/t _____

A

infection that causes vasodilation, leakage and decreased BP

Ex. ruptured appy

18
Q

Thus, thrombin has a role in: primary hemostasis, secondary and regulation (anticoagulation).

what are they

A

induced platelt action and aggregation

binds to thrombomodulin => + protein C => anticoagulation

19
Q

Diagnose endocarditis

A

use a stethoscope (hear whooshing, murmur

20
Q

• Endocarditis is a primary process occurring in the <3: that manifests as

A

splinter cells
painless janeway lesions
Painful osler nodes
roth spots

21
Q

What initial intervention is the best for white thrombo-embolism?

A

• NSAIDS (CHEW ASPIRIN);! they DIRECTLY

22
Q

o Which of the following factors would ensure that areas of the heart are not prone to ischemia?

A

<3 has collateral pathways: allows bypass of areas where thrombus would form and cause infarction

23
Q

fibrinOID necrosis, not

A

finbrinous

24
Q

Marfans may have with TGF-B is _____, with IL-10 is ________

A

TGF-B is antiinflammatory

IL-10: PRO inflammatory

25
Q

High levels of homocysteine and a LDL receptor mutation

A

arteriosclerosis

26
Q

_____________ contributes to arterial and venous thrombosis, as well as the development of atherosclerosis.

A

Elevated levels of homocysteine

27
Q

o If a biopsy was formed, what would we see?

o The microglial cells would contain what? _____

A

Liquifactive necrosis

hemosiderin

28
Q

• Which of the following finding is most likely if there is irreversible myocyte damage?
o Elevated CK BB:
o Elevated CK NB:
o Elevated serum lactate:

A

serum lactate

29
Q

how do we differentiate apotosis from necrosis?

A

acute inflammation

30
Q

What is the most characterstic feature of apoptosis?

A

Chromatin condensation; aggregates periphjerlly, under the nuclear membrane.

31
Q

What is the mediator of acute inflammation is the most likely initiator of leukocyte margination?

A

histamine

32
Q

THE ACTIVE TERMINATION OF SUPARATIVE PROCESS IS MEDIATED BY WHICH ANTI-INFLAMMATORY MEDIATOR?

A

LXA4/B

33
Q

WHHAT PLEITROPIC GF IS ACHEMOTACTIC FOR LEUKOCYTES AND FIBROPLASTS, STIM ECM PROTEIN SYNTHESIS AND SUPRESSES ACUTE INFLAMMATION

A

TGF-B