Cirrhosis

Question 1

perisinusoidal space

Answer 1

where stellate cells are

Question 1

where do stellate cills live

Answer 1

between sinusoid and hepatocyte

Question 2

what do stellate cells store

Answer 2

VITAMIN A

Question 3

what happens to ijured stellayte cells

Answer 3

secrete paracine factors that change the stellate cells

Question 4

changed stellate cells

Answer 4

cant store vit a, proliferate, secrete tgf beta

Question 5

effects of tgf beta

Answer 5

causes stellate cells to produce collagen

Question 6

compression

Answer 6

sinusoids and centralv vein become compressed

Question 7

constant injury effect

Answer 7

leads to constantly activated stellate cells leading to collagen ans then cirrhosis

Question 8

pressure

Answer 8

pressure builds up > intrasinusoidal tension > portal hypertension

Question 9

ascites

Answer 9

when the fluid is puushed into tissues

Question 10

splenomegaly

Answer 10

fluid may back up into spleen

Question 11

hepatorenal filure

Answer 11

blood is pushed aay from liver and so a shunt is created
leading to renal vasoconstriction
low bloodflow in kidneys
low filtration
hepatorenal failure

Question 12

hepatic encephalopathy

Answer 12

liver cant detoxify so ammonia etc backs up and builds up in brain

Question 13

asterexis

Answer 13

ammonia etc causing tremor

Question 14

effect of cirrhosis on oestrogen

Answer 14

oestrogen builds up causing gynaecomastia, palmar erythema and spider angioma/ naevi

Question 15

lab results

Answer 15

unconjugated leading to jaundice
low albumin as liver creates it but cant
reduced clotting factors so increased PR time > easy brusiing