Cirrhosis Flashcards
Which immunological factors are positive in autoimmune hepatitis?
Raised IgG
Antibodies
- ANA
- Anti-smooth muscle
- Anti-soluble liver antigen
What is the diagnostic investigation for autoimmune hepatitis
Liver biopsy and histology
- Shows interface hepatitis and porta plasma cells
Acute autoimmune hepatitis is managed using…
High dose corticosteroids
Complications of autoimmune hepatitis
Liver cirrhosis
Hyperviscosity syndrome: VTE, strokes
Hepatocellular carcinoma
What conditions are associated with autoimmune hepatitis
IBD
Inflammatory endocrine disorders
- Graves
- Autoimmune thyroiditis
- T1 DM
Rheumatological
- RA
- Sjogren’s
What gene (and chromosome) is affected in primary hameochromatosis
HFE gene- chromosome 6
Features of primary haemochromatosis
Affects skin, liver, heart, joints
- Bronze skin, hair loss
- Liver failure
- Cardiac dysfunction
Complications of haemochromatosis
Liver cancer (hepatocellular carcinoma)
T1 diabetes, hypogonadism, hypothyroidism
Cardiomyopathy
Chondrocalcinosis (pseudogout)
Iron studies in haemochromatosis will show…
Elevated serum ferritin and transferrin saturation
What is the first-line management of haemochromatosis
Weekly venesection
Primary sclerosing cholangitis has which genetic associations?
P-ANCA
HLA B8-DR8
What IBD is most associated with PSC?
Ulcerative colitis
What structures are primary affected in PBC
Canals of Hering
- Intralobular hepatic biliary ducts
What sex is PBC more common in?
Women
What immunological markers are associated with PBC?
1- Anti-mitochondrial antibodies
ANA
Raised IgM
