Circulatory, RES & Lymphatics-Viral I Flashcards
Epstein Barr Virus Associated Diseases
Infectious mononucleosis, oral hairy leukoplakia, burkitt’s lymphoma, Hodgkin’s Disease, Nasopharyngeal Carcinoma, PTLD
Commonly afflicts adolescents and adults
infectious mononucleosis
Epstein Barr associated disease that commonly afflicts immunocompromised individuals
Oral Hairy Leukoplakia
Epstein Barr-Oral Hairy Leukoplakia state of viral infection
productive
Epstein Barr-Infectious mononucleosis state of viral infection
productive, but disease due to immunopathology
Epstein Barr-Burkitt’s lymphoma commonly afflicts
Children in central Africa
Epstein Barr associated disease whose viral infections are in the latent state
Hodgkin’s disease, Nasopharyngeal carcinoma, PTLD
Commonly afflicts transplant patients (Epstein-barr associated)
PTLD
Commonly affects individuals living in southeast Asia and China
Nasopharyngeal Carcinoma
Epstein Barr Virus family
Herpesviridae
dsDNA virus, uses C3d component of complement system for attachment and entry, replicates in epithelial and B-cells
Epstein Barr Virus
EBV triggers what to proliferate and produce antibodies ?
B Cells
type of antibodies commonly produced in EBV infection
heterophile antibodies
Latency phase of EBV occurs when
infected B cells survive immune response and become memory B cells
reactivation from latency
usually asymptomatic
CD40 homologue, constitutively active
Latent Membrane Protein 1
increases growth of B cells
Latent Membrane Protein 2
transactivation of EBV transforming genes (LMP1/LMP2), and inhibits apoptosis
Epstein Barr Virus Nuclear Antigen 1 (EBNA1)
Genes involved in EBV carcinogenesis
LMP1, LMP2, EBNA1
transmission through saliva
Epstein-Barr Virus
percent of seropositive adults in the world
90%
Symptoms of mononucleosis
fever, malaise, exudative pharyngitis, splenomegaly, tender lymphadenitis
biochemical marker of infectious mononucleosis
heterophile antibodies
most common in young adulthood in industrialized countries
infectious mononucleosis
pathogenesis of infectious mononucleosis
immune targeting of the infected B cells
EBV and ampicillin treatment may cause
a characteristic rash-immune complexes
Serological markers of Infectious Mononucleosis marking lytic phase-primary infection
EA= EBV Early Antigen, VCA=EBV Viral Capsid Antigen
Serological markers of Infectious Mononucleosis marking latent phase-indicates a past infection
EBNA=Epstein Barr Nuclear Antigen
test that looks for heterophile antibodies: agglutinate if positive
Mono Spot test
In addition to the mono spot test you may test for primary EBV infection
antibodies to EBV (IgM to Viral Capsid Antigen)
atypical monocytes (T cells) found in infectious mononucleosis that have an altered nucleus and indented cell margin-prevalent in EBV infection
Downey Cells
Tx: infectiouis mononucleosis
no vaccines, rest and rehydrate, avoid strenous activity to avoid splenic rupture
plaque like lesion on lateral surface of the tongue due to EBV replicating in the epithelial cells
oral hairy leukoplakia