Ciclo de Krebs Flashcards

1
Q

donde ocurre el ciclo de krebs

A

en la matriz mitocondrial

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2
Q

balance energetico de una vuelta del ciclo de krebs

A

3 NADH
1 FADH
1 GTP
=10 ATP

recuerda q se dan dos vueltas

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3
Q

a cuanto equivale 1 NADH

A

2.5 ATP

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4
Q

a cuanto equivale I FADH

A

1.5 ATP

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5
Q

cuando ocurre la primera descarboxilacion oxidativa en el CK

A

cuando pasa de isocitrato deshidrogenasa a alfa cetoglutarato

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6
Q

cuando ocurre la segunda descarboxilacion oxidativa en el CK

A

cuando pasa de alfa cetoglutarato a succinil CoA

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7
Q

cuando ocurre la fosforilacion a nivel de sustrato en el CK

A

cuando succinil CoA pasa a Succinato y libera GTP

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8
Q

via anaplerotica del citrato

A

-Citrato forma acidos grasos

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9
Q

via anaplerotica del alfa ceto glutarato

A

-alfa ceto glutarato se convierte en glutamato por transaminacion y despues a glutamina

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10
Q

via anaplerotica del succinil coA

A

-Succinil CoA forma hemo y profinas

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11
Q

via anaplerotica del malato

A

-malato forma piruvato por medio de la enzima malica y livera NADPH

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12
Q

via anaplerotica del oxoalacetato

A

-oxoalacetato puede sintetizar glucosa por gluconeogenesis o aminoacidos y pirimidinas

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13
Q

que inhibe la citrato cintasa

A

citrato
ATP
NADH
Succinil CoA

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14
Q

que activa la citrato cintasa

A

ADP
Acetil CoA

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15
Q

que inhibe la isocitrato deshidrogenasa

A

ATP
No se inhibe por productos

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16
Q

que activa la isocitrato deshidrogenasa

A

calcio
ADP

17
Q

que inhibe la alfa ceto glutarato deshidrogenasa

A

NADH
Succinil CoA
Arsenico

18
Q

que activa la alfa cetoglutarato deshidrogenasa

A

calcio
AMP