Chronic Tubulointerstitial Nephritis

Question 1

What is the disease definition?

Answer 1

Chronic inflammation of the renal tubules and interstitium and can progress to end stage renal disease after months or years

Question 2

What is the aetiology?

Answer 2

Medications
Toxins
Infections
Systemic diseases
Metabolic diseases
Miscellaneous

Question 3

What are the clinical features?

Answer 3

Painless Hematuria
Pyuria
Oliguria
Polyuria
Colicky flank pain
Uremia

Question 4

What is the diagnosis?

Answer 4

Lab studies - findings - blood test: increased BUN and creatinine, decreased potassium or increased potassium, anemia of CKD

Urine chemistries - sterile pyuria, proteinuria, Hematuria, RBC casts, WBC casts

Renal ultrasound - small kidneys with echogenicity

Renal biopsy - tubulointerstitial fibrosis and tubular atrophy

Question 5

What is the treatment?

Answer 5

Management of CKD, including treatment off underling cause