Chronic Inflammation/Healing and Repair Processes

Question 1

Chronic Inflammation

Answer 1

Inflammation of prolonged duration or slow progress marked histologically by an infiltration of mononuclear cells (lymphocytes, macrophages, plasma cells) often with proliferation of fibroblasts and fibrosis

Question 2

Chronic Pyelonephritis

Answer 2

Chronic inflammation of the kidney involving the tubules and interstitium which results in scarring

Question 3

Crohn’s Disease

Answer 3

A recurrent granulomatous and chronic inflammatory disorder that usually affects the terminal ileum or colon but may occur at any level of the GI tract; results in extensive scarring and fistulae

Question 4

Diverticulitis

Answer 4

Trapping of fecal material within the diverticular pouch leads to bacterial overgrowth which provokes an inflammator response

Question 5

Diverticulosis

Answer 5

A colonic disease associated with increasing age in whcih small pockets of mucosa protrude through the muscular wall

Question 6

Giant Cells

Answer 6

Fused macrophages with very large cytoplasm and multiple nuclei; Two types (Langhans horshoe arranged nuclei) (Foreign body clustered or random nuclei)

Question 7

Granulation Tissue

Answer 7

so called because grossly, under the scab, it has a granular appearance; characterized by ingrowth of new blood vessels and scar tissue

Question 8

Granuloma

Answer 8

A specific form of chronic inflammatory response to antigens that cannot be eliminated during the acute inflammatory response; characterized histologically by collections of epitheloid macrophages, rim of lymphocytes, giant cells, and caseus necrosis

Question 9

Healing by primary intention

Answer 9

healing, following surgical closure, or a wound where the edges are naturally brought together so that only a minimum amount of scar formation occurs

Question 10

Healing by secondary intention

Answer 10

healing, without the intervention of a surgeon, of a large open wound, leading to extensive scarring

Question 11

Keloid

Answer 11

and exaggerated form of scar that protrudes upward from the skin that is characterized by the presence of dense connective tissue (more prevalent in african americans)

Question 12

Miliary

Answer 12

Multiple minute deposites that resmeble “millet seeds”

Question 13

Scar

Answer 13

A collection of collagen that is the end result of repair of an injury

Question 14

Ulcer

Answer 14

A local tissue defect, or excavation involving the epithelial surface of an organ or tissue (think healing by secondary intention)