Chronic inflammation Flashcards
1
Q
Which cells play a major role in chronic inflammation?
A
lymphocyte
macrophage
2
Q
What are cause of chronic inflammation?
A
PERSISTENCE of Infection
PROLONGED EXPOSURE to insult
AUTO-IMMUNITY
3
Q
What are the cellular players in chronic inflammation?
A
LYMPHOCYTES MACROPHAGES (aka, HISTIOCYTES) PLASMA CELLS EOSINOPHILS MAST CELLS
4
Q
What is the morphology of chronic inflammation?
A
INFILTRATION
TISSUE DESTRUCTION
HEALING
5
Q
What are the components of granulomas(granulomatous inflammation)?
A
FIBROBLASTS
LYMPHS
HISTIOCYTES
GIANT” CELLS
6
Q
What are the types of granuloma?
A
caseating
non caseating
7
Q
What is caveating granuloma?
A
central part becomes acute inflammation
8
Q
What are the systemic manifestations of acute inflammation?
A
FEVER, CHILLS C-Reactive Protein (CRP) “Acute Phase” Reactants, i.e., α1-α2 Erythrocyte Sedimentation Rate (ESR) increases Leukocytosis Pulse, Blood Pressure Cytokine Effects, e.g., TNF(α), IL-1
