Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

inflammation > Acute inflammation > Flashcards

Acute inflammation Flashcards

1
Q

What is the sequence of events in acute inflammation?

A

Normal Histology
Vasodilation
Increased vascular permeability becomes leaky
Leakage of exudate
Margination, Rolling, Adhesion
Transmigration (DIAPEDESIS)
Chemotaxis
PMN Activation
Phagocytosis: Recognition, Attachment, Engulfment, Killing (degradation and digestion)
Termination
100% RESOLUTION, SCAR, or CHRONIC INFLAMMATION are the three possible outcomes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the responses of acute inflammation?

A

protective response

non specific response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what are the main cells involved in inflammation?

A 
Neutrophil
Polymorphonuclear Leukocyte, PMN, PML
Leukocyte”
Granulocyte, Neutrophilic Granulocyte
Poly.”
Polymorph

all the same thing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what are the 5 cardinal signs of inflammation?

A 
rubor(red)
calor(heat)
tumor(swelling)
dolor(pain)
lost of function -(functio laesa)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what are stimuli for acute inflammation?

A 
INFECTIOUS
Tissue Necrosis
    Trauma, physical, and chemical
Foreign Bodies (FBs)
Immune Reactions
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the vascular changes associated with acute inflammation?

A

Changes in Vascular Flow
and Caliber
Increased Vascular
Permeability

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How does increased permeability happen?

A

DILATATION
Endothelial “gaps”injury by bugs or mediatiors
Direct Injury
Leukocyte Injury
Transocytosis (endo/exo) fluid moving from one side of the cell to the other
New Vessels for start for healing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is exudate?

A

mediators opening up the gaps (high protein content and white and red cells)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is extravasation of PMNs?

A

moving outside the blood vessels to endothelial lining

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the steps in extravasation?

A

MARGINATION (PMNs go toward wall)
ROLLING (tumbling and heaping)
ADHESION
TRANSMIGRATION (DIAPEDESIS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the first mediators?

A

Adhesion molecules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What does the adhesion molecules include?

A

glycoproteins
selectins- from endothelial
intergrins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what does adhesion molecules affect?

A

ADHESION and MIGRATION- makes it sticky enough for nuetrophils stick

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is chemotaxis?

A

PMNs going to the site of “injury” AFTER transmigration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What does PMNs do after activated?

A

Produce eicosanoids
undergo degranulation
secrete cytokines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are the eicosonoids produce?

A

arachidonic acid derivatives)
Prostaglandin (and thromboxanes)
Leukotrienes
Lipoxins- important for us to know

17
Q

What are the steps of phagocytosis?

A 
RECOGNITION
ENGULFMENT
KILLING 
    DEGRADATION/  
    DIGESTION

inflammation (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions