chronic and other bs Flashcards
Myelodysplastic syndromes
Myelodysplastic syndromes
Clonal diseases of stem cell origin
characterized by low peripheral cell counts, but usually
hypercellular bone marrow, with abnormal morphology.
They are resistant to chemotherapy, and may turn into acute
leukemia (AML).
Myeloproliferative neoplasms
Myeloproliferative neoplasms
Malignant, clonal diseases of stem cell origin.
Characterized by high peripheral cell counts of certain
cell lines and splenomegaly.
The bone marrow is hypercellular, with
differentiation, without dysplasia
non-Hodgkin’s lymphomas- immature
B-cell ● B-lymphoblastic lymphoma / leukemia T-cell and NK cell ● T-lymphoblastic lymphoma / leukemia
non-Hodgkin’s lymphomas- peripheral mature- b cell
● B-cell CLL / SLL (small lymphocytic lymphoma) ● hairy cell leukemia ● plasma cell myeloma / plasmacytoma ● mantle cell lymphoma ● Burkit’s lymphoma ● follicular lymphoma ● diffuse large B-cell lymphoma
non-hodgking lymphoma -t cell and nk
T cell granular lymphocytic leuk.
● adult T cell lymphoma / leukemia
● mycosis fungoides / Sézary’s sy.
● anaplastic large T cell lymphoma
Chronic Myeloid Leukemia (CML
A neoplasm of the hemopoietic stem cells
It is an MPN ‒ granulocytic overproduction is
dominant, but other myeloid cell lines are also
affected (thrombocytosis is common).
The disease accounts for cca 10‒15% of all
leukemias.
Most common between 20 and 40 years of age.
In the absence of treatment it is a three-phase
disease
Treatment is quite successful
cml natural course
Natural course without treatment Chronic Phase Accumulation of myeloid cells bone marrow peripheral blood spleen and liver elsewhere
Accelerated Phase Further genetic changes in the stem cell leading eventually to acute transformation (ie acute leukemia)
Blast crisis
Acute leukemia (2/3 myeloblastic, 1/3 lymphoblastic)
CML - clinical features of chronic phase
CML - clinical features of chronic phase Peak age 20 to 40 years Weight loss, night sweats Splenomegaly Gout Often found by chance
cml- peripheral and bonemarrow
Peripheral blood film
Anaemia
Leukocytosis (> 25 G/L, sometimes > 100 G/L
WBC differential shows granulocytes in all stages of
maturation
Basophilia, thrombocytosis.
Bone marrow
Hypercellular (reduced fat spaces)
Myeloid:erythroid ratio – 10:1 to 30:1 (N : 2:1)
Myelocyte predominant cell, blasts less 10%
Megakaryocytes increased & dysplastic
Increase reticulin fibrosis in 30-40%