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MOD 1- Lauren > Chp 1: growth factors > Flashcards

Chp 1: growth factors Flashcards

1
Q

epidermal growth factor source

A

activated macrophages
salivary glands
keratinocytes

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2
Q

epidermal growth factor functions

A

mitogenic for keratinocytes and fibroblasts
stimulates keratinocyte migration
stimulates formation of granulation tissue
*overexpressed in breast cancer and other cancers

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3
Q

transforming growth factor alpha source

A

activated macrophages

keratinocytes

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4
Q

transforming growth factor alpha function

A

stimulates proliferation of hepatocytes and many other epithelial cells

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5
Q

hepatocytes growth factor (scatter factor) source

A

-fibroblasts
stromal cells in liver
endothelial cells

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6
Q

hepatocytes growth factor (scatter factor) function

A

-enhances proliferation of hepatocytes and other epithelial cells
increases cell motility
-Overexpressed in Renal and Thyroid Papillary Tumors

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7
Q

vascular endothelial growth factor (VEGF) source

A

mesenchymal cells

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8
Q

vascular endothelial growth factor (VEGF) function

A
  • stimulates proliferation of endothelial cells

- increase vascular permeability

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9
Q

fibroblast growth factor (FGFs)(FGF-1)(FGF-2) source

A
  • macrophages
  • mast cells
  • endothelial cells
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10
Q

fibroblast growth factor (FGFs)(FGF-1)(FGF-2) function

A
  • chemotactic and mitogenic for fibroblasts
  • stimulates angiogenesis and ECM protein synthesis
  • Associated with wound healing, hematopoiesis
  • Binds to heparan sulfate in the ECM at sites of wound healing
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11
Q

transforming growth factor beta source

A
  • platelets
  • t lymphocytes
  • macrophages
  • endothelial cells
  • keratinocytes
  • smooth muscle cells
  • fibroblasts
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12
Q

transforming growth factor beta function

A
  • chemotactic for leukocytes and fibroblasts
  • stimulates ECM protein synthesis
  • suppresses acute inflammation
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13
Q

keratinocyte growth factor (KGF)(FGF-7) source

A

-fibroblasts

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14
Q

keratinocyte growth factor (KGF)(FGF-7) functions

A

-stimulates keratinocyte migration, proliferation and differentiation

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15
Q

platelet derived growth factor (PDGF) source

A
  • platelets
  • macrophages
  • endothelial cells
  • smooth muscle cells
  • keratinocytes
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16
Q

platelet derived growth factor (PDGF) function

A
  • chemotactic for neutrophils, fibroblasts and SMC
  • activates and stimulates proliferation of fibroblasts endothelial and other cells
  • stimulates ECM protein synthesis

MOD 1- Lauren (5 decks)

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