Chapter 3- mediators of inflammation

Question 1

histamine source

Answer 1

-mast cells, basophils, platelets

Question 2

histamine action

Answer 2

-vasodilation, increased vascular permeability, endothelial activation

Question 3

prostaglandins source

Answer 3

-mast cells, leukocytes

Question 4

prostaglandins action

Answer 4

-vasodilation, pain, fever

Question 5

leukotrienes source

Answer 5

-mast cells, leukocytes

Question 6

leukotrienes action

Answer 6

increased vascular permeability, chemotaxis, leukocyte adhesion, and activation

Question 7

cytokines (TNF, IL-1, IL-6) source

Answer 7

-macrophages, endothelial cells, mast cells

Question 8

cytokines (TNF, IL-1, IL-6) local action

Answer 8

-endothelial activation (expression of adhesion molecules)

Question 9

cytokines (TNF, IL-1, IL-6) systemic action

Answer 9

-fever, metabolic abnormalities, hypotension (shock)

Question 10

chemokines source

Answer 10

-leukocytes, activated macrophages

Question 11

chemokines action

Answer 11

-chemotaxis, leukocyte activation

Question 12

platelet activating factor source

Answer 12

-leukocytes, mast cells

Question 13

platelet activating factor action

Answer 13

-vasodilation, increased vascular permeability, leukocyte adhesion, chemotaxis, degranulation, oxidative burst

Question 14

complement source

Answer 14

-plasma (produced in liver)

Question 15

complement action

Answer 15

-leukocyte chemotaxis and activation, direct target killing (MAC), vasodilation (mast cell stimulation)

Question 16

kinins source

Answer 16

-plasma (produced by liver)

Question 17

kinins action

Answer 17

-increased vascular permeability, smooth muscle contraction, vasodilation, pain