Choosing Wisely- Requesting For The Right Immunology Test Flashcards
What does tryptase suggest
Anaphalyaxis
What does oligoclonal bands in CSF suggest
MS
What does monoclonal protein suggest
Myeloma
What the presence of ige suggest
Allergen
What does the presence of iga against tissue transglutaminase suggest
Coeliac disease
What does igg acetylcholinesterase receptor antibodies suggest
Myasthenia gravis
What is the ideal test in terms of specificity and sensitivity
High specifity
High sensitivity
In rheumatoid arthritis what can we look at
Rhematoid factor
Anti ccp
What is rheumatoid factor
Igm autoantibodies directed against igg
What is anti ccp antibodies
An igg autoantibody directed against cyclic citrulinated peptide
To test for allergey what can we lok at
Specific ige
What is coeliac disease
An autoimmune condition cuased by hypersensitivity to gluten
What happens to villous in coeliac disease
Atrophy
How do we screen for coeliac disease
Iga Transglutamine anitbody test
What does an anti nuclear antibody test look for
SLE
What is good pastures syndrome
A rare type of small vessel vasculitis associted with both pulmonary haemand rapidly progressive glomerulonephritis
What is goodpastures syndrome caused by
Anti glomerular basement membrane antibodies (anti-gbm) against type 4 collagen
What are the features of goodpastures syndrome
Pulmonary haemorrhage
Rapidly progressive glomerulonephritis: this can result in AKI. Nephritis can cause proteinuria and haematuria
How can we test for goodpasture syndrome
Anti gbm antibodies
What is vasculitis
Inflammaiton of the small blood vessel without infection
What testing is useful for vasculitis
ANCA testing
What is ANCA
Anti neutrophil cytoplasmic antibodies
What is ANCA associated with i,e the types of small vessel vasculitis
Granulomatosis with polyangiitis
Eosionophillic granulomatosis with polyangiitis
Microscopic polyangiitis
What are the 2 types of ANCA that we test for
Cytoplasmic (cANCA) and perinuclear (pANCA)
What ANCA is granulomatossi with polyangitis associated with
C-ANCA with PR3
What is eosinophillis granulomatosis with polyangitis associated with
P-anca (but this is less prevalent)
What is microscopic polyangitis associated with
P-anca with MPO
