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Immunology > Choosing Wisely- Requesting For The Right Immunology Test > Flashcards

Choosing Wisely- Requesting For The Right Immunology Test Flashcards

1
Q

What does tryptase suggest

A

Anaphalyaxis

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2
Q

What does oligoclonal bands in CSF suggest

A

MS

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3
Q

What does monoclonal protein suggest

A

Myeloma

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4
Q

What the presence of ige suggest

A

Allergen

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5
Q

What does the presence of iga against tissue transglutaminase suggest

A

Coeliac disease

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6
Q

What does igg acetylcholinesterase receptor antibodies suggest

A

Myasthenia gravis

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7
Q

What is the ideal test in terms of specificity and sensitivity

A

High specifity

High sensitivity

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8
Q

In rheumatoid arthritis what can we look at

A

Rhematoid factor

Anti ccp

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9
Q

What is rheumatoid factor

A

Igm autoantibodies directed against igg

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10
Q

What is anti ccp antibodies

A

An igg autoantibody directed against cyclic citrulinated peptide

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11
Q

To test for allergey what can we lok at

A

Specific ige

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12
Q

What is coeliac disease

A

An autoimmune condition cuased by hypersensitivity to gluten

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13
Q

What happens to villous in coeliac disease

A

Atrophy

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14
Q

How do we screen for coeliac disease

A

Iga Transglutamine anitbody test

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15
Q

What does an anti nuclear antibody test look for

A

SLE

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16
Q

What is good pastures syndrome

A

A rare type of small vessel vasculitis associted with both pulmonary haemand rapidly progressive glomerulonephritis

17
Q

What is goodpastures syndrome caused by

A

Anti glomerular basement membrane antibodies (anti-gbm) against type 4 collagen

18
Q

What are the features of goodpastures syndrome

A

Pulmonary haemorrhage

Rapidly progressive glomerulonephritis: this can result in AKI. Nephritis can cause proteinuria and haematuria

19
Q

How can we test for goodpasture syndrome

A

Anti gbm antibodies

20
Q

What is vasculitis

A

Inflammaiton of the small blood vessel without infection

21
Q

What testing is useful for vasculitis

A

ANCA testing

22
Q

What is ANCA

A

Anti neutrophil cytoplasmic antibodies

23
Q

What is ANCA associated with i,e the types of small vessel vasculitis

A

Granulomatosis with polyangiitis
Eosionophillic granulomatosis with polyangiitis
Microscopic polyangiitis

24
Q

What are the 2 types of ANCA that we test for

A

Cytoplasmic (cANCA) and perinuclear (pANCA)

25
Q

What ANCA is granulomatossi with polyangitis associated with

A

C-ANCA with PR3

26
Q

What is eosinophillis granulomatosis with polyangitis associated with

A

P-anca (but this is less prevalent)

27
Q

What is microscopic polyangitis associated with

A

P-anca with MPO

Immunology (7 decks)

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