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Sepsis > Choosing antibiotics > Flashcards

Choosing antibiotics Flashcards

1
Q

What are the 4 C’s?

A

Co-amoxiclav
Cephalosporins
Clindamycin
Ciprofloxacin (ALL QUINOLONES)

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2
Q

Where can anaerobes be found?

A 
Mouth, teeth, throat, sinuses and lower bowel:
Abscesses
Dental infections
Peritonitis
Appendicitis
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3
Q

Where can atypicals be found?

A

Chest and GU:
Pneumonia
Urtheritis
PID

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4
Q

Where can gram positive organisms be found?

A 
Skin and mucous membranes:
Pneumonia
Sinusitis
Cellultis
Osteomyelitis
Wound infection
Line ifnection
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5
Q

Where can gram negative organisms be found?

A 
GI tract:
UTI
Biliary infection
Peritonitis
Pancreatitis
PID
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6
Q

What are general side effects of antibiotics - NOT AN ALLERGY?

A 
Nausea
Vomiting
Diarrhoea
Rashes
Candida infection
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7
Q

What specific side effects are associated with penicillins?

A

Hypersensitivity/ skin reaction

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8
Q

What specific side effects are associated with flucloxacillin and co-amoxiclav?

A

Cholestatic jaundice

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9
Q

What specific side effects are associated with clindamycin, cephalosporins and quinolones?

A

C.difficile colitis

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10
Q

What specific side effects are associated with macrolides?

A

GI disturbances, hepatitis, increased QT

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11
Q

What specific side effects are associated with quinolones?

A

Prolonged QT
Convulsions
Tendonitis and rupture
Rupture of AAA

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12
Q

What specific side effects are associated with aminoglycosides/glycopeptides?

A

Nephrotoxicity

Ototoxicity

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13
Q

What specific side effects are associated with vancomycin?

A

Red man syndrome

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14
Q

What specific side effects are associated with tetracyclines?

A

Hepatotoxicity
Teeth staining
Photosensitivity
Dysphagia

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15
Q

What specific side effects are associated with nitrofurantoin?

A

Peripheral neuropathy

Pulmonary fibrosis

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16
Q

What specific side effects are associated with sulphonamides (co-trimoxaole)?

A

Stevens-johnson syndrome

Blood dyscrasias

17
Q

What specific side effects are associated with trimethoprim?

A

Blood dyscrasias

18
Q

What specific side effects are associated with chloramphenicol?

A

Aplastic anaemia

Grey baby syndrome

19
Q

What specific side effects are associated with linezolid?

A

Blood dyscrasias
MAOI
Optic neuropathy

20
Q

What antibiotics are enzyme inhibitors?

A 
Erythromycin
Clarithromycin
Isoniazid
Metronidazole
Ciprofloxacin
21
Q

What antibiotic is an enzyme inducer?

A

Rifampicin

22
Q

What will reduce the absorption of tetracyclines and quinolones?

A

Antacids

Calcium

23
Q

What will aminoglycosides interact with?

A

Loop diuretics to cause nephrotoxicity

24
Q

What will metronidazole interact with?

A

Alcohol

Reduce lithium

25
Q

What will interact with warfarin?

A

Broad spectrums

INCREASED INR

26
Q

What is an immediate onset reaction (type 1)?

A

Occurs within 1 hour of administration of the drug

IgE mediated that may progress to anaphylaxis

Sepsis (7 decks)

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