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Unit 2 drugs > Cholinomimetics > Flashcards

Cholinomimetics Flashcards

1
Q

Bethanechol

Class
Mechanism
Therapy
Important side effects

A

Direct acting carbamic acid ester

Direct acting muscarinic cholinomimetic

Post-op and neurogenic ileus

SLUDGE

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2
Q

Muscarine

Class
Mechanism
Therapy
Important side effects

A

Direct acting non-ester alkaloid

Direct muscarinic cholinomimetic

No Tx?

SLUDGE

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3
Q

Pilocarpine

Class
Mechanism
Therapy
Important side effects

A

Direct acting non-ester alkaloid

Direct muscarinic cholinomimetic

Glaucoma (ACh activates sphincter and ciliary muscles of eye)

SLUDGE

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4
Q

Cevimeline

Class
Mechanism
Therapy
Important side effects

A

Direct acting non-ester alkaloid

Direct muscarinic cholinomimetic

Dry mouth (increases salivation)

SLUDGE

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5
Q

Nicotine

Class
Mechanism
Therapy
Important side effects

A

Direct acting non-ester alkaloid

Direct nicotinic cholinomimetic

Smoking cessation

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6
Q

Neostigmine

Mechanism
Therapy
Important side effects

A

AChE inhibitor (short acting)

post op and neurogenic ileus
urinary retention
mysathenia gravis
reversal of neuromuscular blockade

SLUDGE + general increase in cholinergic signaling
Paralysis

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7
Q

Physostigmine

Mechanism
Therapy
Important side effects

A

AChE inhibitor (short acting)

Glaucoma (contraction of papillary muscles in eye)

SLUDGE + general increase in cholinergic signaling
Paralysis

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8
Q

Donepazil

Mechanism
Therapy
Important side effects

A

AChE inhibitor

Crosses BBB
Alzheimer’s

SLUDGE + general increase in cholinergic signaling
Paralysis

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9
Q

Edrophonium

Mechanism
Therapy
Important side effects

A

AChE inhibitor (short acting) [5-15 mins]

mysathenia gravis (used to differentiate from ACh crisis)

SLUDGE + general increase in cholinergic signaling
Paralysis

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10
Q

Echothiophate

Mechanism
Therapy
Important side effects

A

AChE inhibitor Long acting (>100hrs)

Gluacoma treatment

SLUDGE + general increase in cholinergic signaling
Paralysis

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11
Q

Pralidoxine

Mechanism
Therapy
Important side effects

A

Strong nucleophile

regenerates phosporylated AChE before aging occurs

Tx: organophosphate and sarin gas poisoning

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12
Q

Sarin

Mech
Tx
Side Eff

A

AChE inhibitor

Volatile nerve gas

SLUDGE + general increase in cholinergic signaling
Paralysis
Death

9treat w/ prlidoxine and atropine before aging)

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Unit 2 drugs (6 decks)

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