Cholinergic receptor antagonists Flashcards

1
Q

Atropine

Mech
Tx
Side Eff

A

Blocks Musc Receptors

Tx: Myadriasis and cyclopelegia (Const. pupil and inability to focus)

General block of Musc fxn

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2
Q

Scopolamine

Mech
Tx
Side Eff

A

Blocks Musc Receptors

Tx: Prevent/reduce motion sickness

General block of Musc fxn

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3
Q

Dicyclomine

Mech
Tx
Side Eff

A

Blocks Musc Receptors

Tx: reduce transient hypermotility

General block of Musc fxn

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4
Q

Tropicamide

Mech
Tx
Side Eff

A

Blocks Musc Receptors

Tx: Myadriasis and cyclopelegia (Const. pupil and inability to focus)
Very short acting

General block of Musc fxn

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5
Q

Tolterodine

Mech
Tx
Side Eff

A

Blocks Musc Receptors

Tx: transient cystitis, post op bladder spasm, incontinence

General block of Musc fxn

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6
Q

Benztropine

Mech
Tx
Side Eff

A

Blocks Musc Receptors

Crosses BBB
Tx: Parkinson’s manifestations

General block of Musc fxn

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7
Q

Ipratropium

Mech
Tx
Side Eff

A

Blocks Musc Receptors

Tx: Bronchodilation in COPD or asthma

General block of Musc fxn

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8
Q

Tiotropium

Mech
Tx
Side Eff

A

Blocks Musc Receptors

Tx: Bronchodilation in COPD or asthma
(longer acting that ipratropium)

General block of Musc fxn

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9
Q

Hexamethonium

Mech
Tx
Side Eff

A

Blocks ganglionic (Nn) Receptor and sympathetic tone

Tx: Hypertensive crisis, “bloodless” field surgery

Rarely used

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10
Q

Mecamyline

Mech
Tx
Side Eff

A

Blocks ganglionic (Nn) Receptor and sympathetic tone

Tx: Hypertensive crisis, “bloodless” field surgery

rarely used

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11
Q

Succinyl Choline

Mech
Tx
Side Eff

A

Overstim. of the nicotinic receptor –> desnsitization of muscle unit
Produces flaccid paralysis w/in 1 minute

tx: brief procedures (tracheal intubation, reset dislocated joints)

Resp. paralysis, disturbance of autonomic fxn

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12
Q

Tubocurarine

Mech
Tx
Side Eff

A

Blocks Nm receptor

Tx: muscle relaxant for surgery w/o deep anesthesia
(lasts 30-60 mins)

Resp. paralysis, disturbance of autonomic fxn

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13
Q

Mivacurium

Mech
Tx
Side Eff

A

Blocks Nm receptor

Tx: muscle relaxant for surgery w/o deep anesthesia
(rapidly hydrolyzed)

Resp. paralysis, disturbance of autonomic fxn

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14
Q

Botulinum Toxin A

Mech
Tx
Side Eff

A

Local Paralytic
Blocks ACh Vesicles from being released by degrading SNAP-25 (synaptobrevin)

Reduce wrinkles, achalasia, strabismus, oromandibular dystonia

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