Cholinergic receptor antagonists Flashcards
Atropine
Mech
Tx
Side Eff
Blocks Musc Receptors
Tx: Myadriasis and cyclopelegia (Const. pupil and inability to focus)
General block of Musc fxn
Scopolamine
Mech
Tx
Side Eff
Blocks Musc Receptors
Tx: Prevent/reduce motion sickness
General block of Musc fxn
Dicyclomine
Mech
Tx
Side Eff
Blocks Musc Receptors
Tx: reduce transient hypermotility
General block of Musc fxn
Tropicamide
Mech
Tx
Side Eff
Blocks Musc Receptors
Tx: Myadriasis and cyclopelegia (Const. pupil and inability to focus)
Very short acting
General block of Musc fxn
Tolterodine
Mech
Tx
Side Eff
Blocks Musc Receptors
Tx: transient cystitis, post op bladder spasm, incontinence
General block of Musc fxn
Benztropine
Mech
Tx
Side Eff
Blocks Musc Receptors
Crosses BBB
Tx: Parkinson’s manifestations
General block of Musc fxn
Ipratropium
Mech
Tx
Side Eff
Blocks Musc Receptors
Tx: Bronchodilation in COPD or asthma
General block of Musc fxn
Tiotropium
Mech
Tx
Side Eff
Blocks Musc Receptors
Tx: Bronchodilation in COPD or asthma
(longer acting that ipratropium)
General block of Musc fxn
Hexamethonium
Mech
Tx
Side Eff
Blocks ganglionic (Nn) Receptor and sympathetic tone
Tx: Hypertensive crisis, “bloodless” field surgery
Rarely used
Mecamyline
Mech
Tx
Side Eff
Blocks ganglionic (Nn) Receptor and sympathetic tone
Tx: Hypertensive crisis, “bloodless” field surgery
rarely used
Succinyl Choline
Mech
Tx
Side Eff
Overstim. of the nicotinic receptor –> desnsitization of muscle unit
Produces flaccid paralysis w/in 1 minute
tx: brief procedures (tracheal intubation, reset dislocated joints)
Resp. paralysis, disturbance of autonomic fxn
Tubocurarine
Mech
Tx
Side Eff
Blocks Nm receptor
Tx: muscle relaxant for surgery w/o deep anesthesia
(lasts 30-60 mins)
Resp. paralysis, disturbance of autonomic fxn
Mivacurium
Mech
Tx
Side Eff
Blocks Nm receptor
Tx: muscle relaxant for surgery w/o deep anesthesia
(rapidly hydrolyzed)
Resp. paralysis, disturbance of autonomic fxn
Botulinum Toxin A
Mech
Tx
Side Eff
Local Paralytic
Blocks ACh Vesicles from being released by degrading SNAP-25 (synaptobrevin)
Reduce wrinkles, achalasia, strabismus, oromandibular dystonia