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IC > Cholingergic Pharm > Flashcards

Cholingergic Pharm Flashcards

1
Q

Acetylcholine

A

Cholinoceptor agonist
Rapidly hydrolyzed
Both muscarinic and nicotinic action

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2
Q

Methacholine

A

Cholinoceptor agonist
Moderate resistance to hydrolysis
Only muscarinic activity

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3
Q

Carbachol chloride

A

Cholinoceptor agonist
Resistant to hydrolysis (long half life)
Both muscarinic and nicotinic action

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4
Q

Bethanechol Chloride

A

Cholinoceptor agonist
Resistant to hydrolysis (long half life)
Only muscarinic action

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5
Q

Edrophonium

A

Cholinesterase inhibitor
Short half life
Simple alcohol with quaternary ammonium group

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6
Q

Neostigmine

A

Cholinesterase inhibitor
Carbamate (quaternary structure)
Insoluble in lipids

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7
Q

Physostigmine

A

Cholinesterase Inhibitor
Carbamate (tertiary structure)
Distributes in CNS

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8
Q

Echothiophate

A

Cholinesterase inhibitor
Oranophosphate
NOT well absorbed topically

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9
Q

Nicotine

A

Direct nicotinic agonist

Toxicity (acute) causes CNS stimulation, respiratory paralysis, HTN, and cardiac arrhythmias

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10
Q

Varenicline

A

Direct nicotinic agonist

Used for smoking cessation

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11
Q

Cevimeline

A

Direct muscarinic agonist

Choline ester

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12
Q

Pilocarpine

A

Direct muscarinic agonist

Alkaloid

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13
Q

Pyridostigmine

A

Cholinesterase inhibitor

Carbamate

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14
Q

Rivastigmine

A

Cholinesterase inhibitor

Carbamate

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15
Q

Ambenonium

A

Cholinesterase inhibitor

Carbamate

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16
Q

Demecarium

A

Cholinesterase inhibitor

Carbamate

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17
Q

Carbaryl

A

Cholinesterase inhibitor

Carbamate

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18
Q

Soman

A

Cholinesterase inhibitor

Organophosphate

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19
Q

Sarin

A

Cholinesterase inhibitor

Organophosphate

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20
Q

Parathion

A

Cholinesterase inhibitor

Organophosphate

21
Q

Malathion

A

Cholinesterase inhibitor

Organophosphate

22
Q

Isoflurophate

A

Cholinesterase inhibitor

Organophosphate

23
Q

Diisopropylfluorophosphate (DFP)

A

Cholinesterase inhibitor

Organophosphate

24
Q

Donepezil

A

Cholinesterase inhibitor

25
Q

Tacrine

A

Cholinesterase inhibitor

26
Q

Galantamine

A

Cholinesterase inhibitor

27
Q

Atropine

A

Cholinoceptor blocker
Reversible competitive
Acts on M1, M2 and M3 subtypes

28
Q

Scopolamine

A

Muscarinic antagonist

Tertiary amine

29
Q

Homatropine

A

Muscarinic antagonist

Tertiary amine

30
Q

Pirenzepine

A

Muscarinic antagonist

Tertiary amine

31
Q

Tropicamide

A

Muscarinic antagonist

Tertiary amine

32
Q

Tolterodine

A

Muscarinic antagonist

Tertiary amine

33
Q

Dicyclomine

A

Muscarinic antagonist

Tertiary amine

34
Q

Fesoteridine

A

Muscarinic antagonist

Tertiary amine

35
Q

Mepenzolate

A

Muscarinic antagonist

Tertiary amine

36
Q

Solifenacin

A

Muscarinic antagonist

Tertiary amine

37
Q

Oxybutynin

A

Muscarinic antagonist

Tertiary amine

38
Q

Darifenacin

A

Muscarinic antagonist

Tertiary amine

39
Q

Trospium

A

Muscarinic antagonist

Tertiary amine

40
Q

Atropine methyl nitrate

A

Muscarinic antagonist

Quaternary amine

41
Q

Methscopolamine

A

Muscarinic antagonist

Quaternary amine

42
Q

Ipratropium

A

Muscarinic antagonist

Quaternary amine

43
Q

Propantheline

A

Muscarinic antagonist

Quaternary amine

44
Q

Glycopyrrolate

A

Muscarinic antagonist

Quaternary amine

45
Q

Hexamethonium

A

Ganglion blocking drug

Prototypic

46
Q

Trimethaphan

A

Ganglion blocking drug

Lacks CNS effects

47
Q

Mecamylamine

A

Ganglionic blocking drug

48
Q

Pralidoxime

A

Cholinesterase regenerator

IC (5 decks)

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