Cholingergic Pharm Flashcards
Acetylcholine
Cholinoceptor agonist
Rapidly hydrolyzed
Both muscarinic and nicotinic action
Methacholine
Cholinoceptor agonist
Moderate resistance to hydrolysis
Only muscarinic activity
Carbachol chloride
Cholinoceptor agonist
Resistant to hydrolysis (long half life)
Both muscarinic and nicotinic action
Bethanechol Chloride
Cholinoceptor agonist
Resistant to hydrolysis (long half life)
Only muscarinic action
Edrophonium
Cholinesterase inhibitor
Short half life
Simple alcohol with quaternary ammonium group
Neostigmine
Cholinesterase inhibitor
Carbamate (quaternary structure)
Insoluble in lipids
Physostigmine
Cholinesterase Inhibitor
Carbamate (tertiary structure)
Distributes in CNS
Echothiophate
Cholinesterase inhibitor
Oranophosphate
NOT well absorbed topically
Nicotine
Direct nicotinic agonist
Toxicity (acute) causes CNS stimulation, respiratory paralysis, HTN, and cardiac arrhythmias
Varenicline
Direct nicotinic agonist
Used for smoking cessation
Cevimeline
Direct muscarinic agonist
Choline ester
Pilocarpine
Direct muscarinic agonist
Alkaloid
Pyridostigmine
Cholinesterase inhibitor
Carbamate
Rivastigmine
Cholinesterase inhibitor
Carbamate
Ambenonium
Cholinesterase inhibitor
Carbamate
Demecarium
Cholinesterase inhibitor
Carbamate
Carbaryl
Cholinesterase inhibitor
Carbamate
Soman
Cholinesterase inhibitor
Organophosphate
Sarin
Cholinesterase inhibitor
Organophosphate
Parathion
Cholinesterase inhibitor
Organophosphate
Malathion
Cholinesterase inhibitor
Organophosphate
Isoflurophate
Cholinesterase inhibitor
Organophosphate
Diisopropylfluorophosphate (DFP)
Cholinesterase inhibitor
Organophosphate
Donepezil
Cholinesterase inhibitor
Tacrine
Cholinesterase inhibitor
Galantamine
Cholinesterase inhibitor
Atropine
Cholinoceptor blocker
Reversible competitive
Acts on M1, M2 and M3 subtypes
Scopolamine
Muscarinic antagonist
Tertiary amine
Homatropine
Muscarinic antagonist
Tertiary amine
Pirenzepine
Muscarinic antagonist
Tertiary amine
Tropicamide
Muscarinic antagonist
Tertiary amine
Tolterodine
Muscarinic antagonist
Tertiary amine
Dicyclomine
Muscarinic antagonist
Tertiary amine
Fesoteridine
Muscarinic antagonist
Tertiary amine
Mepenzolate
Muscarinic antagonist
Tertiary amine
Solifenacin
Muscarinic antagonist
Tertiary amine
Oxybutynin
Muscarinic antagonist
Tertiary amine
Darifenacin
Muscarinic antagonist
Tertiary amine
Trospium
Muscarinic antagonist
Tertiary amine
Atropine methyl nitrate
Muscarinic antagonist
Quaternary amine
Methscopolamine
Muscarinic antagonist
Quaternary amine
Ipratropium
Muscarinic antagonist
Quaternary amine
Propantheline
Muscarinic antagonist
Quaternary amine
Glycopyrrolate
Muscarinic antagonist
Quaternary amine
Hexamethonium
Ganglion blocking drug
Prototypic
Trimethaphan
Ganglion blocking drug
Lacks CNS effects
Mecamylamine
Ganglionic blocking drug
Pralidoxime
Cholinesterase regenerator