Cholinesterase inhibitors

Question 1

Ambenonium,

Echothiophate

Answer 1

quaternary & charged AChE inhibitors that is poorly absorbed

Question 2

Donepezil, galantamine

Answer 2

used to treat patients with progressive dementia of the Alzheimer type with def. of intact cholinergic neruons

Question 3

Edrophonium

Answer 3

reverse paralysis induced by neuromuscular blocking drugs during surgical anesthesia

Question 4

Neostigmine

Answer 4

quaternary carbamate AChE inhibitor that has additional direct nicotinic agonist effects at the NMJ

used to reverse paralysis induced by neuromuscular blocking drugs during surgical anesthesia

Question 5

Physostigmine

Answer 5

Tertiary & uncharged AChE inhibitors that are well absorbed

approved to treat dementia

can also be used to treat overdoses

Question 6

Pyridostigmine

Answer 6

reduces incapacitation & mortality associated with n. agent poisoning

Question 7

Rivastigmine

Answer 7

tertiary & uncharged AChE inhibitor

approved to treat progressive dementia of Alzheimer types with def. of intact cholinergic neurons

Question 8

Tacrine

Answer 8

approved to treat dementia but due to high incidence of hepatoxicity, newer agents preferred

Tertiary & uncharged