Cholinesterase Inhibitor Poisoning - Toxicology Flashcards
1
Q
What are the three “Killer B’s” of organophosphate poisoning?
A
Bradycardia
Bronchoconstriction
Bronchorrhea
2
Q
What is the first drug administered in an anticholinesterase poisoning if bronchorrhea and/or bronchospasm are present?
A
Atropine 2-5 mg IV/IO/IM q. 5 min
Titrate to the drying of secretions and improved ventilation
Can treat concurrently with the bronchospasm/asthma directive
3
Q
If a patient is experiencing organophosphate poisoning what should be administered after atropine?
A
Pralidoxime (2-pam)
1-2g over 5-10 min. q 1 hr prn
Note: pralidoxime not indicated for carbamate poisoning (carbamates are insecti- and herbicides that reversibly bind to AchE and spontaneously disassociate, 2-pam can actually lengthen the AchE inactivation)
