CHOLINERGIC RECEPTORS

Question 1

What are the types of cholinergic receptors

Answer 1

Nicotinic receptor Nn, Nm
Muscarinic receptor M1,M2, M3, M4, M5

Question 2

Where are Nn receptors found

Answer 2

Found at the ganglion (where pre and post ganglionic neurons meet)

Question 3

Where are Nm receptors found

Answer 3

(Not ANS, somatic PNS)
Found in skeletal muscle

Question 4

Where are muscarinic receptors found

Answer 4

M1, M2, M3- ANS (found at the effectors organs of most post ganglionic neurons)
M4, M5- CNS

Question 5

What’s the distribution of the muscarinic receptors

Answer 5

M1: Stomach
M2: Heart
M3: All other effector organs
M4, M5; Brain

Question 6

What’s the mechanism of the Nicotinic receptor

Answer 6

Ionotropic

Question 7

What’s the mechanism of each muscarinic receptor

Answer 7

Metabotropic
M1: Gq (PKC, PLC, IP3, DAG)
M2: Gi (AC, CAMP, PKA)
M3: Gq (PKC, PLC, IP3, DAG)

Question 8

Which cholinergic receptor affects the eyes and it’s effect

Answer 8

M3
Myosis (pupillary constriction)

Question 9

Which cholinergic receptor affects the salivary glands and it’s effect

Answer 9

M3, M1
Much watery saliva

Question 10

Which cholinergic receptor affects the lungs and it’s effect

Answer 10

M3
Bronchoconstriction

Question 11

Which cholinergic receptor affects the heart and it’s effect

Answer 11

M2
Decreased HR and FC

Question 12

Which cholinergic receptor affects the GIT and it’s effect

Answer 12

M1, M3
Increased motility and decreased feacal retention

Question 13

Which cholinergic receptor affects the urinary tract and it’s effect

Answer 13

M3
Urine excretion

Question 14

Which cholinergic receptor affects the liver and it’s effect

Answer 14

M3
Glycogenesis

Question 15

Which cholinergic receptor affects the kidney and it’s effect

Answer 15

M3
Inhibit RAAS

Question 16

Which cholinergic receptor affects fat and it’s effect

Answer 16

M3
Lipogenesis

Question 17

Which cholinergic receptor affects the genitals and it’s effect

Answer 17

M3
Erection